Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 57413..57839 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP085625 | ||
| Organism | Escherichia coli strain EC71 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | LJN53_RS25400 | Protein ID | WP_001372321.1 |
| Coordinates | 57413..57538 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 57615..57839 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJN53_RS25360 (52786) | 52786..53475 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| LJN53_RS25365 (53662) | 53662..54045 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| LJN53_RS25370 (54366) | 54366..54968 | + | 603 | WP_077782435.1 | transglycosylase SLT domain-containing protein | - |
| LJN53_RS25375 (55265) | 55265..56086 | - | 822 | WP_001234469.1 | DUF932 domain-containing protein | - |
| LJN53_RS25380 (56204) | 56204..56491 | - | 288 | WP_000107544.1 | hypothetical protein | - |
| LJN53_RS25385 (56516) | 56516..56722 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| LJN53_RS25390 (56792) | 56792..56965 | + | 174 | Protein_76 | hypothetical protein | - |
| LJN53_RS25395 (56963) | 56963..57193 | - | 231 | WP_001426396.1 | hypothetical protein | - |
| LJN53_RS25400 (57413) | 57413..57538 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| LJN53_RS25405 (57480) | 57480..57629 | - | 150 | Protein_79 | plasmid maintenance protein Mok | - |
| - (57615) | 57615..57839 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (57615) | 57615..57839 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (57615) | 57615..57839 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (57615) | 57615..57839 | - | 225 | NuclAT_0 | - | Antitoxin |
| LJN53_RS25410 (57651) | 57651..57839 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| LJN53_RS25415 (57808) | 57808..58570 | - | 763 | Protein_81 | plasmid SOS inhibition protein A | - |
| LJN53_RS25420 (58567) | 58567..59001 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| LJN53_RS25425 (59056) | 59056..59253 | - | 198 | Protein_83 | hypothetical protein | - |
| LJN53_RS25430 (59281) | 59281..59514 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| LJN53_RS25435 (59577) | 59577..60116 | - | 540 | WP_001825195.1 | single-stranded DNA-binding protein | - |
| LJN53_RS25440 (60142) | 60142..60348 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| LJN53_RS25445 (60418) | 60418..60498 | + | 81 | Protein_87 | hypothetical protein | - |
| LJN53_RS25450 (60681) | 60681..60850 | - | 170 | Protein_88 | hypothetical protein | - |
| LJN53_RS25455 (61444) | 61444..62415 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | dfrA17 / blaTEM-1B / tet(B) / catA1 / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..82796 | 82796 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T220967 WP_001372321.1 NZ_CP085625:c57538-57413 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T220967 NZ_CP117317:c4257798-4257307 [Salmonella enterica subsp. enterica serovar Derby]
ATGATCTCCCCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGCCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATCCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
ATGATCTCCCCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGCCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATCCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA
Antitoxin
Download Length: 225 bp
>AT220967 NZ_CP085625:c57839-57615 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
