Detailed information of TA system TA022094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1534607..1535331
• Replicon: chromosome
• Accession: NC_009483
• Organism: Geobacter uraniireducens Rf4

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: A5GA92
• Locus tag: GURA_RS06615
• Protein ID: WP_011938218.1
• Coordinates: 1534607..1534906 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: GURA_RS23300
• Protein ID: WP_011938219.1
• Coordinates: 1534909..1535331 (+)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GURA_RS06600	1530707..1531042	+	336	WP_011938215.1	DUF1622 domain-containing protein	-
GURA_RS06605	1531072..1532631	+	1560	WP_198134532.1	efflux transporter outer membrane subunit	-
GURA_RS06610	1532734..1534452	-	1719	WP_041245801.1	B12-binding domain-containing radical SAM protein	-
GURA_RS06615	1534607..1534906	+	300	WP_011938218.1	type II toxin-antitoxin system MqsR family toxin	Toxin
GURA_RS23300	1534909..1535331	+	423	WP_011938219.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
GURA_RS06625	1535762..1537099	+	1338	WP_011938221.1	radical SAM protein	-
GURA_RS06630	1537395..1537664	-	270	WP_011938222.1	hypothetical protein	-
GURA_RS06635	1537927..1538202	-	276	WP_011938223.1	acylphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-98)

Antitoxin

• Zinc finger, MqsA-type (10-53)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11662.64 Da
• Isoelectric Point: 10.0311

>T22094 WP_011938218.1 NC_009483:1534607-1534906 [Geobacter uraniireducens Rf4]
MEKRRPHYDLKSIQAQMDCIEAMNLTMTARHGIKAIGMALGDALVVIKRLSMGNFYKAMTVHADSRVWQDVYHAEWKGRA
LYIKFQRHEEFFIVSFKER

Nucleotide

• Length: 300 bp

>T22094 NC_009483:1534607-1534906 [Geobacter uraniireducens Rf4]
ATGGAAAAGCGACGTCCCCATTATGACCTCAAGTCGATCCAGGCACAGATGGACTGCATTGAGGCAATGAACCTGACCAT
GACCGCCCGACACGGCATCAAAGCGATCGGAATGGCCTTGGGAGATGCGCTGGTGGTAATCAAGAGGCTTTCAATGGGAA
ATTTTTATAAGGCCATGACAGTTCATGCGGACAGCAGGGTTTGGCAAGATGTATATCACGCTGAATGGAAAGGAAGGGCC
TTGTACATCAAGTTTCAGCGACACGAAGAATTCTTTATCGTGTCGTTCAAGGAGCGTTGA

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 15623.75 Da
• Isoelectric Point: 8.1333

>AT22094 WP_011938219.1 NC_009483:1534909-1535331 [Geobacter uraniireducens Rf4]
MSKQWNGKTCPACFQGTLEHRVKRTQFEYRSNILEYDQEGAWCGTCGEGIVTGKEAAAAESLLDDFIARVDKEEASELAR
IRKKLGLNQKEAAMIAGGGHNAFSRYERGEARPVAAVVNLFRLLDRHPELLNELKKQKAA

Nucleotide

• Length: 423 bp

>AT22094 NC_009483:1534909-1535331 [Geobacter uraniireducens Rf4]
ATGAGTAAACAATGGAACGGGAAAACATGTCCCGCATGTTTTCAGGGAACTTTGGAACATCGGGTGAAACGGACGCAATT
TGAGTACCGCAGCAACATTCTGGAATACGACCAGGAAGGGGCTTGGTGCGGCACATGTGGTGAAGGGATCGTCACTGGAA
AAGAAGCGGCTGCCGCTGAATCGTTGCTTGACGATTTCATTGCCCGTGTGGACAAGGAAGAGGCTTCCGAACTGGCCCGC
ATCAGAAAGAAGCTCGGACTTAACCAGAAGGAGGCGGCCATGATCGCCGGTGGCGGCCACAACGCCTTCTCTCGCTACGA
GAGGGGTGAAGCCAGACCCGTTGCCGCTGTAGTGAACCTCTTCCGTCTGCTGGACCGGCATCCTGAGCTGCTGAACGAAT
TGAAAAAGCAAAAAGCCGCATAG

Structures

Toxin

• AlphaFold DB: A5GA92