Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1431721..1432318 Replicon chromosome
Accession NC_009483
Organism Geobacter uraniireducens Rf4

Toxin (Protein)


Gene name higB Uniprot ID A5GAH0
Locus tag GURA_RS06205 Protein ID WP_011938141.1
Coordinates 1431721..1432002 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag GURA_RS06210 Protein ID WP_011938142.1
Coordinates 1432013..1432318 (+) Length 102 a.a.

Genomic Context

GURA_RS06190GURA_RS06195GURA_RS06200GURA_RS06205GURA_RS06210GURA_RS24140GURA_RS06215GURA_RS06220GURA_RS23285
Location: 1427264..1428589 (1326 bp)
Type: Others
Protein ID: WP_011938138.1
Location: 1428818..1430803 (1986 bp)
Type: Others
Protein ID: WP_011938139.1
Location: 1430894..1431583 (690 bp)
Type: Others
Protein ID: WP_011938140.1
Location: 1431721..1432002 (282 bp)
Type: Toxin
Protein ID: WP_011938141.1
Location: 1432013..1432318 (306 bp)
Type: Antitoxin
Protein ID: WP_011938142.1
Location: 1433131..1433817 (687 bp)
Type: Others
Protein ID: WP_157046138.1
Location: 1434056..1434916 (861 bp)
Type: Others
Protein ID: WP_041245790.1
Location: 1435232..1435633 (402 bp)
Type: Others
Protein ID: WP_011938144.1
Location: 1435635..1435823 (189 bp)
Type: Others
Protein ID: WP_083764790.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GURA_RS061901427264..1428589+1326WP_011938138.1electron transfer flavoprotein subunit alpha-
GURA_RS061951428818..1430803+1986WP_011938139.14Fe-4S dicluster domain-containing protein-
GURA_RS062001430894..1431583+690WP_011938140.1type 1 glutamine amidotransferase-
GURA_RS062051431721..1432002+282WP_011938141.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GURA_RS062101432013..1432318+306WP_011938142.1HigA family addiction module antidote proteinAntitoxin
GURA_RS241401433131..1433817+687WP_157046138.1hypothetical protein-
GURA_RS062151434056..1434916+861WP_041245790.1AraC family transcriptional regulator-
GURA_RS062201435232..1435633-402WP_011938144.1type II toxin-antitoxin system HicB family antitoxin-
GURA_RS232851435635..1435823-189WP_083764790.1type II toxin-antitoxin system HicA family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(3-98)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10854.22 Da        Isoelectric Point: 7.1342

>T22092 WP_011938141.1 NC_009483:1431721-1432002 [Geobacter uraniireducens Rf4]
MINSFRCKETEKLFNGKFSSKLPQAIQRLAARKLDYLDGAGDLDDLRSPPGNRLETLKDDRAGQHSIRINDQWRICFVWR
DNNAFDVEIVDYH

Download         Length: 282 bp

>T22092 NC_009483:1431721-1432002 [Geobacter uraniireducens Rf4]
ATGATCAATTCCTTTAGGTGCAAAGAAACTGAAAAGTTATTCAACGGCAAATTTTCCTCCAAGTTGCCACAGGCAATACA
GCGCCTTGCCGCTCGAAAACTTGACTATCTGGATGGTGCCGGGGATCTTGATGACTTGCGTTCCCCTCCCGGAAACCGTC
TGGAAACTTTAAAGGATGATCGCGCCGGACAACACAGCATTCGCATTAATGACCAGTGGCGCATCTGTTTTGTATGGCGT
GACAATAACGCCTTCGATGTCGAAATCGTTGACTACCATTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11621.51 Da        Isoelectric Point: 9.5598

>AT22092 WP_011938142.1 NC_009483:1432013-1432318 [Geobacter uraniireducens Rf4]
MSKRDFPPIHPGEILREEFLIPLGISQYRLAKEIHVPARRINEIVLEKRGISADTALRLGRYFGTTAQLWINLQARYDLE
VARDAIEDKLEAEIKPLKRAA

Download         Length: 306 bp

>AT22092 NC_009483:1432013-1432318 [Geobacter uraniireducens Rf4]
ATGAGCAAAAGAGATTTTCCTCCAATTCATCCTGGTGAAATCTTGCGCGAAGAATTTCTAATTCCGCTTGGTATCAGTCA
GTACCGACTCGCAAAGGAAATACACGTTCCGGCTCGTCGCATAAACGAGATCGTACTTGAAAAGCGTGGGATTTCCGCGG
ATACCGCGCTTCGCCTGGGACGCTATTTCGGCACGACGGCGCAGCTTTGGATTAACCTGCAAGCACGGTATGATCTTGAG
GTAGCGCGTGACGCGATTGAAGATAAGCTGGAAGCTGAAATTAAGCCATTGAAAAGGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA5GAH0

Antitoxin

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Source
ID
Structure
No matching records found

References