Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 1113871..1114489 | Replicon | chromosome |
| Accession | NZ_CP085525 | ||
| Organism | Sinorhizobium meliloti strain L6-AK89 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q92R61 |
| Locus tag | LJD24_RS05270 | Protein ID | WP_010969011.1 |
| Coordinates | 1114193..1114489 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | LJD24_RS05265 | Protein ID | WP_010969010.1 |
| Coordinates | 1113871..1114179 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJD24_RS05220 (LJD24_05220) | 1108950..1109270 | - | 321 | WP_003527320.1 | YnfA family protein | - |
| LJD24_RS05225 (LJD24_05225) | 1109345..1109518 | - | 174 | WP_010969006.1 | hypothetical protein | - |
| LJD24_RS05230 (LJD24_05230) | 1109532..1109705 | - | 174 | WP_003527318.1 | hypothetical protein | - |
| LJD24_RS05235 (LJD24_05235) | 1109941..1110642 | + | 702 | WP_010969007.1 | glutathione S-transferase N-terminal domain-containing protein | - |
| LJD24_RS05240 (LJD24_05240) | 1110866..1111207 | - | 342 | WP_010969008.1 | DUF2147 domain-containing protein | - |
| LJD24_RS05245 (LJD24_05245) | 1111792..1112058 | + | 267 | WP_003527312.1 | sel1 repeat family protein | - |
| LJD24_RS05250 (LJD24_05250) | 1112080..1113201 | - | 1122 | WP_010969009.1 | pyridoxal phosphate-dependent aminotransferase | - |
| LJD24_RS05260 (LJD24_05260) | 1113630..1113860 | - | 231 | WP_026029805.1 | hypothetical protein | - |
| LJD24_RS05265 (LJD24_05265) | 1113871..1114179 | - | 309 | WP_010969010.1 | HigA family addiction module antitoxin | Antitoxin |
| LJD24_RS05270 (LJD24_05270) | 1114193..1114489 | - | 297 | WP_010969011.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LJD24_RS05275 (LJD24_05275) | 1114537..1114842 | - | 306 | WP_003527305.1 | hypothetical protein | - |
| LJD24_RS05280 (LJD24_05280) | 1115170..1116207 | + | 1038 | WP_017271047.1 | porin | - |
| LJD24_RS05285 (LJD24_05285) | 1116317..1117384 | - | 1068 | WP_014526650.1 | site-specific integrase | - |
| LJD24_RS05290 (LJD24_05290) | 1117425..1118474 | - | 1050 | WP_017271048.1 | porin | - |
| LJD24_RS05295 (LJD24_05295) | 1118688..1119176 | - | 489 | WP_013844230.1 | BA14K family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11677.11 Da Isoelectric Point: 6.7260
>T220826 WP_010969011.1 NZ_CP085525:c1114489-1114193 [Sinorhizobium meliloti]
VIVGFRDDWLRTFFVDDVRSRNIPYDLEARLFRKLQMIDDAATDQDLRVPPSNHFEKLRGNLAGLHSIRVNQQWRLIFRW
DGTRGEADGIYLDDHSYR
VIVGFRDDWLRTFFVDDVRSRNIPYDLEARLFRKLQMIDDAATDQDLRVPPSNHFEKLRGNLAGLHSIRVNQQWRLIFRW
DGTRGEADGIYLDDHSYR
Download Length: 297 bp
>T220826 NZ_CP117294:4680787-4681098 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11588.44 Da Isoelectric Point: 11.0603
>AT220826 WP_010969010.1 NZ_CP085525:c1114179-1113871 [Sinorhizobium meliloti]
MLTTKRKPATVGEILTEEFMRPMGLTQGALAEAMGVQRKHVNELCGNRRNVTAATALILARVFGNSPDFWLNVQRRNDLW
LVMNTPKERERIERARPLENAA
MLTTKRKPATVGEILTEEFMRPMGLTQGALAEAMGVQRKHVNELCGNRRNVTAATALILARVFGNSPDFWLNVQRRNDLW
LVMNTPKERERIERARPLENAA
Download Length: 309 bp
>AT220826 NZ_CP117294:4681095-4681541 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|