Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 90888..91539 | Replicon | plasmid pNDM_NMG38-2 |
| Accession | NZ_CP085482 | ||
| Organism | Proteus sp. NMG38-2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A857SB97 |
| Locus tag | LG402_RS21105 | Protein ID | WP_042847389.1 |
| Coordinates | 91189..91539 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A8I2DDI8 |
| Locus tag | LG402_RS21100 | Protein ID | WP_042847390.1 |
| Coordinates | 90888..91187 (-) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LG402_RS21080 (LG402_21075) | 86026..86910 | - | 885 | WP_000155092.1 | Mph(E) family macrolide 2'-phosphotransferase | - |
| LG402_RS21085 (LG402_21080) | 86966..88441 | - | 1476 | WP_000052512.1 | ABC-F type ribosomal protection protein Msr(E) | - |
| LG402_RS21090 (LG402_21085) | 88891..89595 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| LG402_RS21095 (LG402_21090) | 89731..90747 | - | 1017 | WP_042847391.1 | hypothetical protein | - |
| LG402_RS21100 (LG402_21095) | 90888..91187 | - | 300 | WP_042847390.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LG402_RS21105 (LG402_21100) | 91189..91539 | - | 351 | WP_042847389.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LG402_RS21110 (LG402_21105) | 91724..92287 | + | 564 | WP_227336994.1 | recombinase family protein | - |
| LG402_RS21115 (LG402_21110) | 92418..92765 | + | 348 | WP_042847387.1 | hypothetical protein | - |
| LG402_RS21120 (LG402_21115) | 93044..93370 | + | 327 | WP_042847386.1 | PerC family transcriptional regulator | - |
| LG402_RS21125 (LG402_21120) | 93459..93848 | + | 390 | WP_042847385.1 | hypothetical protein | - |
| LG402_RS21130 (LG402_21125) | 93877..94581 | + | 705 | WP_042847384.1 | hypothetical protein | - |
| LG402_RS21135 (LG402_21130) | 94596..95135 | + | 540 | WP_042847383.1 | hypothetical protein | - |
| LG402_RS21140 (LG402_21135) | 95199..95789 | + | 591 | WP_166268309.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | sul2 / aph(3'')-Ib / aph(6)-Id / floR / lnu(G) / ant(2'')-Ia / catB8 / blaOXA-10 / ant(3'')-Ia / dfrA1 / qacE / sul1 / blaNDM-1 / ARR-3 / mph(E) / msr(E) | - | 1..262556 | 262556 | |
| - | inside | IScluster/Tn | lnu(G) / ant(2'')-Ia / catB8 / blaOXA-10 / ant(3'')-Ia / dfrA1 / qacE / sul1 / blaNDM-1 / ARR-3 / mph(E) / msr(E) | - | 61197..92287 | 31090 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13437.50 Da Isoelectric Point: 5.2661
>T220785 WP_042847389.1 NZ_CP085482:c91539-91189 [Proteus sp. NMG38-2]
MWEILTRDLFDSWFEEQNEETQIEVLAVLMILREDGPNLGRPQVDTLKGSQFPNMKELRIQVGGHPIRACFAFDPIRRGI
VLCAGDKKGKDETRFYKKLIKMADAEYAAHLLEQEK
MWEILTRDLFDSWFEEQNEETQIEVLAVLMILREDGPNLGRPQVDTLKGSQFPNMKELRIQVGGHPIRACFAFDPIRRGI
VLCAGDKKGKDETRFYKKLIKMADAEYAAHLLEQEK
Download Length: 351 bp
>T220785 NZ_CP117291:c3907085-3906798 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 10990.70 Da Isoelectric Point: 7.0171
>AT220785 WP_042847390.1 NZ_CP085482:c91187-90888 [Proteus sp. NMG38-2]
MSTLNELLAKQSPETLAKIEDRAEEIRREITLAKIREELKLSQTELAQSLGVSQPSIAKLENVDNDPKLSTLKRYIKALG
GELSIDVTLPNGKRIGLHL
MSTLNELLAKQSPETLAKIEDRAEEIRREITLAKIREELKLSQTELAQSLGVSQPSIAKLENVDNDPKLSTLKRYIKALG
GELSIDVTLPNGKRIGLHL
Download Length: 300 bp
>AT220785 NZ_CP117291:c3906811-3906509 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|