Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 909707..910353 Replicon chromosome
Accession NZ_CP085478
Organism Klebsiella pneumoniae strain Kp1604

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag LI478_RS04615 Protein ID WP_016529833.1
Coordinates 910006..910353 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LI478_RS04610 Protein ID WP_002920557.1
Coordinates 909707..910006 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LI478_RS04590 905913..906671 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
LI478_RS04595 906721..907551 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LI478_RS04600 907602..907931 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LI478_RS04605 908136..909644 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LI478_RS04610 909707..910006 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LI478_RS04615 910006..910353 - 348 WP_016529833.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LI478_RS04620 910529..912976 - 2448 WP_021312822.1 glycogen phosphorylase -
LI478_RS04625 912994..914427 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T220763 WP_016529833.1 NZ_CP085478:c910353-910006 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T220763 NZ_CP117288:c2179281-2178514 [Streptococcus dysgalactiae subsp. equisimilis]
ATGAAACTAGAAGAATTTAGTCAAGATAATTTTGAACAAGCCTCCAAACGACTCGTTCGTTCTTTAACTCGTGGAAAAAC
AACCTCATCTCAGCCTAAGGCTATTTTGCTCGGTGGACAGAGTGGTGCTGGGAAAACAACGATCCATCGAATTAAACAAA
GGGAATTTCAAGGTAATATCATTATTATTGATGGAGATAGTTATCGCTCTTTTCATCCGAACTACCTTGGCCTACAGGAA
AGGTATGGCAAAGATAGTGTGGATTATACCAAAGTATTCGCGGGACAAATGGTTGAATATCTTGTAGATGAGTTGAGTAA
AAAAGGTTATCATTTATTAATCGAGGGTACCTTGAGAACAACAGAAGTTCCCAAAAAAACTGCACAATTATTGACAACTA
AAGGTTACCAAGTCTCACTTGCAGTAATTGCGACCAAGCCAGAATTGTCCTATCTCAGTACCTTGATACGTTATGAAGAG
CTCCATGCTATAGACCCTAGTCAAGCTAGAGCGACTCCCAAAGAGCACCATGATGGAATTGTAGAACATTTAGTTGATAA
CTTACGAGAGTTAGAAAATGACAAAATTTTTAATCAAATTCAAATTTATCAAAGAGATCAATCGTGTATTTATGATTCGC
AAGTAGATCAAATCTCAGCAGCAGAAGTTTTACAAGAATGCCTCTTCGGAAAATGGAGTAAGGTGGAGGAAGAGATGTTG
AAGTTGGGACAGGAACGGTTGAAAGAGCTGGGGGAAATTGATAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT220763 WP_002920557.1 NZ_CP085478:c910006-909707 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT220763 NZ_CP117288:c2179757-2179281 [Streptococcus dysgalactiae subsp. equisimilis]
ATGATTGGAGAAAATATTAAAACGTTACGCAAGGCACATAATCTAACTCAGCCTGAGTTCGCAAAGATTGTTGGTATCTC
TCGAAATAGTCTGAGTCGTTATGAAAATGGGACAAGTCGAGTTTCGACAGAATTAATAGATCGTATCTGCAAGAAATTTA
ATGTTTCTTATATCGATATCGTAGGGGAGGAAAAAATGCTCACACCAGTAGAAGATTATCAGTTAACTCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTTCAAGATGAACAAGGAATTGCATTTGATGATAC
TTCTAATCCTTGGGTTCTAATGAGCGATGATTTGTCTGATTTAATTAACACGAAGATTTATCTTGTTGCAACTTTTGAGG
ATATAGAGCGATTTAATGGCTATTTGGATGGCATTGAACGTATGCTAGAACAAGCTACTCATCTGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9BBY1

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References