Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 177406..178130 Replicon chromosome
Accession NZ_CP085344
Organism Cupriavidus sp. MP-37

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag LIN44_RS00885 Protein ID WP_227313152.1
Coordinates 177406..177702 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag LIN44_RS00890 Protein ID WP_227313153.1
Coordinates 177732..178130 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN44_RS00870 (LIN44_00870) 173077..174045 + 969 WP_227313149.1 M48 family metallopeptidase -
LIN44_RS00875 (LIN44_00875) 174139..176217 + 2079 WP_227313150.1 S8 family peptidase -
LIN44_RS00880 (LIN44_00880) 176287..177234 - 948 WP_227313151.1 N-acetyl-gamma-glutamyl-phosphate reductase -
LIN44_RS00885 (LIN44_00885) 177406..177702 + 297 WP_227313152.1 type II toxin-antitoxin system MqsR family toxin Toxin
LIN44_RS00890 (LIN44_00890) 177732..178130 + 399 WP_227313153.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
LIN44_RS00895 (LIN44_00895) 178154..178930 - 777 WP_062796369.1 exodeoxyribonuclease III -
LIN44_RS00900 (LIN44_00900) 178958..179662 + 705 WP_227313154.1 orotate phosphoribosyltransferase -
LIN44_RS00905 (LIN44_00905) 179753..181060 + 1308 WP_227313155.1 patatin-like phospholipase family protein -
LIN44_RS00910 (LIN44_00910) 181082..181891 - 810 WP_227313156.1 polyphosphate kinase 2 family protein -
LIN44_RS00915 (LIN44_00915) 181990..182856 - 867 WP_227313157.1 diaminopimelate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-96)

Antitoxin

Antitoxin MqsA

(3-130)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11308.32 Da        Isoelectric Point: 10.0669

>T220720 WP_227313152.1 NZ_CP085344:177406-177702 [Cupriavidus sp. MP-37]
MEKGTAHYPLRHVKALLLAGKMKMTFAAYSHAAMMGLRWLGVRDILVRLEPGDFYKSMTTYEDHRVWQDVYRPVTPHGAL
YVKLTVTDEVLVVSFKPR

Download         Length: 297 bp

>T220720 NZ_CP117256:c372117-371824 [Rhizobium tumorigenes]
ATGAGTTTTAAGCTTTCTGTCGAGGCGGAAGAAGACATTATTGCGATCGCCCAGCAGGGTGCCCGTATGTTCGGAGTAGA
TCAGGCAAAACGCTACCACGATGAACTTTTCGCATTATTTGATCTGATAGCTGCTGACCCACGCATCGCGCGCGAACGGA
ATGAGATCGAACCGCCCATCAGAATTCATCCCTTCAAAGCACATCTCATCGTCTATCGGGTTGAAGATGATGAGAAAATT
TTCGTAGTGCGAATTCGCCACGGGCATGAAGATTGGGAAAGTATTTCAATGTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14615.85 Da        Isoelectric Point: 5.9047

>AT220720 WP_227313153.1 NZ_CP085344:177732-178130 [Cupriavidus sp. MP-37]
MKCPECGGAELVAGMRDMPYTYRGETTVIPNVPGQWCPNCGEGVLPRDSDWVSDAMLAFNRQVNAALVDPAFITEVRKKL
RLDQREAAEIFGGGVNAFSRYETGRTKPPLALIKLLKLLDRHPELLDEVRAA

Download         Length: 399 bp

>AT220720 NZ_CP117256:c372356-372114 [Rhizobium tumorigenes]
ATGGCGACAATGAACGTATCTCTTCCAGACCCGATGAAGGATTGGGTGGAGGCGCAGGCTAGGACCGGGCGATATTCGAA
CGCTAGTGACTACGTACGCGACTTGATCAGACGCGACCAGACACGAAACGACAAGATTGCCGCCATGCAAAGCTTCGTCG
AGGCCAGGCTCCAAAGTGGCGTTGGCATTCGATCGAAGGATGAACTCTTCGCTGAGGCGATGGCTCGTACCAGCGAGTCA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References