Detailed information of TA system TA220710

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 361782..362119
• Replicon: chromosome
• Accession: NZ_CP085294
• Organism: Enterococcus faecalis strain EFS108

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: E2Z0W4
• Locus tag: LIT97_RS01660
• Protein ID: WP_002381035.1
• Coordinates: 361782..361925 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	361857..362119 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIT97_RS01640	357879..358517	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
LIT97_RS01645	359203..360819	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
LIT97_RS01650	361149..361292	+	144	WP_002392818.1	type I toxin-antitoxin system toxin PepG1	-
LIT97_RS01655	361411..361551	+	141	WP_073340360.1	putative holin-like toxin	-
LIT97_RS01660	361782..361925	+	144	WP_002381035.1	putative holin-like toxin	Toxin
-	361857..362119	-	263	-	-	Antitoxin
LIT97_RS01665	362120..366811	-	4692	WP_002394774.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5202.20 Da
• Isoelectric Point: 10.0041

>T220710 WP_002381035.1 NZ_CP085294:361782-361925 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKENNKK

Nucleotide

• Length: 144 bp

>T220710 NZ_CP117255:c974023-973733 [Rhizobium tumorigenes]
GTGATCGAAGTCCGGCAGACCGCTATCTTTGCGAATTGGCTCGATGCGCTCCGAGACGCGCAGGCGCGCCAACGCATCGT
CGTTCGCATCCGGCGGCTCGAACTTGGCAACCCCGGAGATATCAAGCCGGTCGGTGAAGGTGTCAGCGAAATGCGCATTA
CCCATGGCCCCGGCTACCGACTCTATTTCACCCGATCCGGCGACATGATCGTCGTTCTCTTATGCGGCGGCGACAAGTCA
TCGCAAGCAAGGGACATCGCGATCGCCCGGCAATTGGCTAAGGAGATTTGA

Antitoxin

Nucleotide

• Length: 263 bp

>AT220710 NZ_CP085294:c362119-361857 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Toxin

• AlphaFold DB: A0A2Z6BWH2

Antitoxin