Detailed information of TA system TA220693

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 209715..210199
• Replicon: chromosome
• Accession: NZ_CP085294
• Organism: Enterococcus faecalis strain EFS108

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LIT97_RS00975
• Protein ID: WP_075551663.1
• Coordinates: 209715..209816 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	209990..210199 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIT97_RS00950	205240..206193	-	954	WP_227297505.1	siderophore ABC transporter substrate-binding protein	-
LIT97_RS00955	206232..206987	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LIT97_RS00960	206984..207949	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
LIT97_RS00965	207946..208893	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
LIT97_RS00970	209078..209530	+	453	WP_002354958.1	YueI family protein	-
LIT97_RS00975	209715..209816	-	102	WP_075551663.1	putative holin-like toxin	Toxin
-	209990..210199	+	210	-	-	Antitoxin
LIT97_RS00980	210148..210249	-	102	WP_075551663.1	putative holin-like toxin	-
LIT97_RS00985	210439..212709	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LIT97_RS00990	212880..213380	+	501	WP_002354954.1	cysteine hydrolase family protein	-
LIT97_RS00995	213683..214579	+	897	WP_002365354.1	YitT family protein	-
LIT97_RS01000	214630..215028	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T220693 WP_075551663.1 NZ_CP085294:c209816-209715 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T220693 NZ_CP117244:2079145-2079248 [Salmonella enterica subsp. enterica serovar Typhimurium]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 210 bp

>AT220693 NZ_CP085294:209990-210199 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin