Detailed information of TA system TA220687

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-RNAII/Fst(toxin)
• Location: 28267..28508
• Replicon: plasmid pEFS36_1
• Accession: NZ_CP085292
• Organism: Enterococcus faecalis strain EFS36

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: LIT96_RS14935
• Protein ID: WP_002360667.1
• Coordinates: 28267..28377 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	28417..28508 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIT96_RS14915 (25157)	25157..25747	+	591	Protein_28	Cna B-type domain-containing protein	-
LIT96_RS15290 (25829)	25829..26107	+	279	Protein_29	Cna B-type domain-containing protein	-
LIT96_RS14925 (26159)	26159..27673	+	1515	WP_264481171.1	Cna B-type domain-containing protein	-
LIT96_RS14930 (27973)	27973..28185	+	213	WP_033604193.1	hypothetical protein	-
LIT96_RS14935 (28267)	28267..28377	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
- (28417)	28417..28508	-	92	NuclAT_0	-	Antitoxin
- (28417)	28417..28508	-	92	NuclAT_0	-	Antitoxin
- (28417)	28417..28508	-	92	NuclAT_0	-	Antitoxin
- (28417)	28417..28508	-	92	NuclAT_0	-	Antitoxin
LIT96_RS14940 (28617)	28617..28913	+	297	WP_002360665.1	replication control protein PrgN	-
LIT96_RS14945 (29167)	29167..29949	+	783	WP_002360664.1	ParA family protein	-
LIT96_RS14950 (29942)	29942..30298	+	357	WP_002360663.1	hypothetical protein	-
LIT96_RS14955 (30557)	30557..31567	+	1011	WP_002399363.1	replication initiator protein A	-
LIT96_RS14960 (31738)	31738..32571	+	834	WP_227316580.1	TraB domain-containing protein	-
LIT96_RS14965 (32640)	32640..33244	+	605	Protein_38	IS3-like element IS1485 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aac(6')-aph(2'') / ant(6)-Ia / aph(3')-III / erm(B) / lsa(E) / lnu(B)	-	1..43405	43405

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T220687 WP_002360667.1 NZ_CP085292:28267-28377 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T220687 NZ_CP117244:206806-207291 [Salmonella enterica subsp. enterica serovar Typhimurium]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Nucleotide

• Length: 92 bp

>AT220687 NZ_CP085292:c28508-28417 [Enterococcus faecalis]
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT

Structures

Antitoxin