Detailed information of TA system TA220678

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1615839..1616062
• Replicon: chromosome
• Accession: NZ_CP085291
• Organism: Enterococcus faecalis strain EFS36

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LIT96_RS07825
• Protein ID: WP_075551663.1
• Coordinates: 1615839..1615940 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1615885..1616062 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIT96_RS07805	1611061..1611459	+	399	WP_002354951.1	glyoxalase	-
LIT96_RS07810	1611510..1612406	-	897	WP_002368434.1	YitT family protein	-
LIT96_RS07815	1612709..1613209	-	501	WP_002370089.1	cysteine hydrolase family protein	-
LIT96_RS07820	1613380..1615650	+	2271	WP_227316461.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LIT96_RS07825	1615839..1615940	+	102	WP_075551663.1	putative holin-like toxin	Toxin
-	1615889..1616099	-	211	-	-	-
LIT96_RS07830	1616125..1616577	-	453	WP_002354958.1	YueI family protein	-
LIT96_RS07835	1616762..1617709	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
LIT96_RS07840	1617706..1618671	+	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
LIT96_RS07845	1618668..1619423	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LIT96_RS07850	1619462..1620415	+	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T220678 WP_075551663.1 NZ_CP085291:1615839-1615940 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T220678 NZ_CP117242:879001-879321 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Nucleotide

• Length: 178 bp

>AT220678 NZ_CP085291:c1616062-1615885 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Structures

Antitoxin