Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 1464735..1465071 Replicon chromosome
Accession NZ_CP085291
Organism Enterococcus faecalis strain EFS36

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag LIT96_RS07150 Protein ID WP_002396786.1
Coordinates 1464928..1465071 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 1464735..1464784 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIT96_RS07145 1460042..1464733 + 4692 WP_010815866.1 WxL domain-containing protein -
- 1464735..1464784 - 50 - - Antitoxin
LIT96_RS07150 1464928..1465071 - 144 WP_002396786.1 putative holin-like toxin Toxin
LIT96_RS07155 1465401..1467017 - 1617 WP_002370154.1 phosphatase PAP2/LCP family protein -
LIT96_RS07160 1467479..1468774 + 1296 WP_010815865.1 ATP-binding protein -
LIT96_RS07165 1468783..1469415 + 633 WP_002358972.1 RloB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T220674 WP_002396786.1 NZ_CP085291:c1465071-1464928 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T220674 NZ_CP117238:c2379498-2379232 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 50 bp

>AT220674 NZ_CP085291:c1464784-1464735 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References