Detailed information of TA system TA220646

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 964504..964766
• Replicon: chromosome
• Accession: NZ_CP085289
• Organism: Enterococcus faecalis strain EFS17

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: LIT95_RS04660
• Protein ID: WP_002392696.1
• Coordinates: 964623..964766 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	964504..964649 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIT95_RS04645	959869..960582	-	714	WP_002354877.1	trehalose operon repressor	-
LIT95_RS04650	960844..963588	+	2745	WP_126254803.1	glycosyl hydrolase family 65 protein	-
LIT95_RS04655	963603..964253	+	651	WP_010824266.1	beta-phosphoglucomutase	-
-	964504..964649	+	146	-	-	Antitoxin
LIT95_RS04660	964623..964766	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
LIT95_RS04665	964998..965969	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
LIT95_RS04670	966144..966581	-	438	WP_227264204.1	peptide-methionine (R)-S-oxide reductase MsrB	-
LIT95_RS04675	966714..967268	-	555	WP_002354869.1	Maf family protein	-
LIT95_RS04680	967293..969425	-	2133	WP_126254804.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T220646 WP_002392696.1 NZ_CP085289:c964766-964623 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T220646 NZ_CP117232:2300-2647 [Escherichia coli]
ATGTGGACGGTACTTTTTAGCCAGCGATTTGACGGCTGGCTAAATGAGCAAGAAGACGCTCTTCAGGAAAAGGTTTTGGC
TGATTTGAAAAAGCTACAGGTTTACGGACCTGAGTTACCCAGGCCATATGCCGATACCGTAAAAGGTTCTCGGTACAAAA
ATATGAAAGAGCTTCGCGTTCAGTTTTCTGGCCGTCCGATAAGAGCCTTTTATGCGTTCGATCCGATTCGCCGGGCTATC
GTTCTTTGTGCAGGAGACAAAAGTAACGATAAGCGGTTTTATAAAAAACTGGTGCGTATAGCTGAGGATGAGTTTGCAGC
ACATCTGAACACACTGGAGAGCAAGTAA

Antitoxin

Nucleotide

• Length: 146 bp

>AT220646 NZ_CP085289:964504-964649 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin