Detailed information of TA system TA220643

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 896991..897214
• Replicon: chromosome
• Accession: NZ_CP085289
• Organism: Enterococcus faecalis strain EFS17

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: LIT95_RS04350
• Protein ID: WP_021164442.1
• Coordinates: 897113..897214 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	896991..897176 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIT95_RS04325	892608..893561	-	954	WP_126254760.1	siderophore ABC transporter substrate-binding protein	-
LIT95_RS04330	893600..894355	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
LIT95_RS04335	894352..895317	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
LIT95_RS04340	895314..896261	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
LIT95_RS04345	896446..896898	+	453	WP_126254759.1	YueI family protein	-
-	896991..897176	+	186	-	-	Antitoxin
LIT95_RS04350	897113..897214	-	102	WP_021164442.1	putative holin-like toxin	Toxin
LIT95_RS04355	897405..899675	-	2271	WP_002354955.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
LIT95_RS04360	899846..900352	+	507	WP_126254758.1	cysteine hydrolase family protein	-
LIT95_RS04365	900542..901438	+	897	WP_002365354.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3625.38 Da
• Isoelectric Point: 4.5869

>T220643 WP_021164442.1 NZ_CP085289:c897214-897113 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T220643 NZ_CP117230:c2118305-2118096 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Nucleotide

• Length: 186 bp

>AT220643 NZ_CP085289:896991-897176 [Enterococcus faecalis]
AAAAGAGAGGTATACGGGTACATACCTCTCCTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAACGCAACAAGGGTTGCA

Structures

Antitoxin