Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1846477..1846702 Replicon chromosome
Accession NZ_CP085202
Organism Shigella flexneri strain P099

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag IUX27_RS08910 Protein ID WP_000813254.1
Coordinates 1846547..1846702 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 1846477..1846535 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUX27_RS08875 1841654..1842916 - 1263 Protein_1718 tyrosine-type recombinase/integrase -
IUX27_RS08885 1843254..1844051 - 798 WP_001325918.1 DgsA anti-repressor MtfA -
IUX27_RS08895 1844262..1845312 - 1051 Protein_1720 tyrosine-type recombinase/integrase -
IUX27_RS08900 1845312..1845452 - 141 Protein_1721 DUF4224 domain-containing protein -
IUX27_RS08905 1845479..1845895 + 417 WP_005069274.1 hypothetical protein -
- 1846477..1846535 - 59 - - Antitoxin
IUX27_RS08910 1846547..1846702 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
IUX27_RS08915 1846870..1847148 + 279 WP_011069426.1 hypothetical protein -
IUX27_RS08920 1847150..1848208 + 1059 WP_001265248.1 DUF968 domain-containing protein -
IUX27_RS08925 1848209..1848574 + 366 WP_000140020.1 RusA family crossover junction endodeoxyribonuclease -
IUX27_RS08930 1848571..1849259 + 689 Protein_1727 bacteriophage antitermination protein Q -
IUX27_RS08955 1850055..1850270 + 216 WP_000839572.1 class II holin family protein -
IUX27_RS08960 1850369..1851043 + 675 WP_004967157.1 IS66-like element accessory protein TnpA -
IUX27_RS08965 1851040..1851390 + 351 WP_005048975.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 1809376..1871718 62342


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T220614 WP_000813254.1 NZ_CP085202:1846547-1846702 [Shigella flexneri]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T220614 NZ_CP117203:c1893153-1893001 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 59 bp

>AT220614 NZ_CP085202:c1846535-1846477 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References