Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 73140..73654 Replicon plasmid pDSM109990_a
Accession NZ_CP085145
Organism Sulfitobacter dubius strain DSM 109990

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag DSM109990_RS16610 Protein ID WP_243263450.1
Coordinates 73388..73654 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag DSM109990_RS16605 Protein ID WP_243263449.1
Coordinates 73140..73391 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSM109990_RS16575 (DSM109990_03359) 68868..69602 + 735 WP_243263443.1 IS30 family transposase -
DSM109990_RS16580 (DSM109990_03360) 69716..69970 + 255 WP_243263444.1 type II toxin-antitoxin system HicA family toxin -
DSM109990_RS16585 (DSM109990_03361) 69967..70314 + 348 WP_243263445.1 type II toxin-antitoxin system HicB family antitoxin -
DSM109990_RS16590 (DSM109990_03362) 70358..70684 - 327 WP_243263446.1 endoribonuclease MazF -
DSM109990_RS16595 (DSM109990_03363) 70686..70928 - 243 WP_243263447.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
DSM109990_RS16600 (DSM109990_03364) 71569..72918 + 1350 WP_243263448.1 Fic family protein -
DSM109990_RS16605 (DSM109990_03365) 73140..73391 + 252 WP_243263449.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DSM109990_RS16610 (DSM109990_03366) 73388..73654 + 267 WP_243263450.1 Txe/YoeB family addiction module toxin Toxin
DSM109990_RS16615 (DSM109990_03368) 73776..75098 - 1323 WP_243263451.1 glutamine synthetase family protein -
DSM109990_RS16620 (DSM109990_03369) 75109..76047 - 939 WP_243263452.1 MurR/RpiR family transcriptional regulator -
DSM109990_RS16625 (DSM109990_03370) 76272..77417 + 1146 WP_243263453.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..284454 284454


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10530.01 Da        Isoelectric Point: 9.8911

>T220522 WP_243263450.1 NZ_CP085145:73388-73654 [Sulfitobacter dubius]
VKLVFSEQAWEDYQHWVSTNDKVHERINELIKQCKRTPLKGTGKPEPLKGDLTGWWSRRISQEDRMVYRVKRMGDGQSLE
IAQLRFHY

Download         Length: 267 bp

>T220522 NZ_CP117054:c771466-771179 [Vibrio harveyi]
ATGAAAGTAGTCTGGTCTCCATTAGCACTTCAGAAACTAGGTGATGCAGCGGAGTTTATTTCTTTGGATAATCCACCTGC
AGCAGAGAGGTGGGTAAACGAAGTTTTTGATAAAACTGAACTACTTGGAAGTATGCCTGAAATGGGGCGGTTTGTTCCTG
AAATGCCCCACACGAACTATCGCGAAATCATCTTTGGTCACTATCGTATTATCTACAGTTTAAGTCACGAAATCCGCGTA
CTAACAGTTCGTAATTGTCGTCAAATTTTATCGGAAGATGACGTGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9152.26 Da        Isoelectric Point: 5.0481

>AT220522 WP_243263449.1 NZ_CP085145:73140-73391 [Sulfitobacter dubius]
MDVMTYSDARAHLKDVMDRAINDKQEVVVTRKKGESVVVVSLDTWNAVNETLHLLSTPNNASRLRASIAQLDAGTGNERD
LAE

Download         Length: 252 bp

>AT220522 NZ_CP117054:c771744-771463 [Vibrio harveyi]
ATGAGTCGTATTCATTTCGATCAAGATATTCAGCCTTTGTCTGAGTTTCGTGCCGGTGTAGCTTCATACATCAAACAAAT
CAATGAGACTCGTCGTCCATTGGTTATTACTCAACGTGGAAAAGGTGTTGCTGTTGTTCTCGATGTTGCTGAGTATGAAG
CAATGCAAGAGAAAATCGAATTACTGGAAGAAATGCGCACAGCAGAAGCTCAGTTAGCTTCTGGTCTCGGTGTTTCCAAT
GATGATGCGCGTGCTCAAGTACTTGGGCGCATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References