Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1276342..1276988 Replicon chromosome
Accession NZ_CP085094
Organism Aggregatibacter actinomycetemcomitans strain 5S

Toxin (Protein)


Gene name higB Uniprot ID X2JQ23
Locus tag LIN95_RS06610 Protein ID WP_005555126.1
Coordinates 1276342..1276692 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID X2JT85
Locus tag LIN95_RS06615 Protein ID WP_005540827.1
Coordinates 1276689..1276988 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN95_RS06590 1271520..1271765 - 246 WP_005540815.1 YgjV family protein -
LIN95_RS06595 1271955..1273292 - 1338 WP_249849246.1 argininosuccinate synthase -
LIN95_RS06600 1273387..1274214 - 828 WP_233115378.1 SDR family NAD(P)-dependent oxidoreductase -
LIN95_RS06605 1274571..1276154 + 1584 WP_005567417.1 peptide chain release factor 3 -
LIN95_RS06610 1276342..1276692 + 351 WP_005555126.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN95_RS06615 1276689..1276988 + 300 WP_005540827.1 helix-turn-helix transcriptional regulator Antitoxin
LIN95_RS06620 1277024..1279957 - 2934 WP_005567421.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
LIN95_RS06625 1280159..1280386 + 228 WP_005567423.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13518.64 Da        Isoelectric Point: 9.9664

>T220485 WP_005555126.1 NZ_CP085094:1276342-1276692 [Aggregatibacter actinomycetemcomitans]
MWAVILTERFETWLNQQPIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRVQHSGRAIRLFFAFDPKRRAI
VLCGGDKGNDKRFYRTMIRIADQELNHYLATMEQTK

Download         Length: 351 bp

>T220485 NZ_CP117049:2754903-2755010 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11342.12 Da        Isoelectric Point: 5.8598

>AT220485 WP_005540827.1 NZ_CP085094:1276689-1276988 [Aggregatibacter actinomycetemcomitans]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRVFQI

Download         Length: 300 bp

>AT220485 NZ_CP117049:c2754856-2754790 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X2JQ23

Antitoxin

Source ID Structure
AlphaFold DB X2JT85

References