220470

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1505527..1506093 Replicon chromosome
Accession NZ_CP085092
Organism Aggregatibacter actinomycetemcomitans strain 30R

Toxin (Protein)


Gene name higB Uniprot ID X2JU35
Locus tag LIN94_RS07525 Protein ID WP_005543444.1
Coordinates 1505527..1505805 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LIN94_RS07530 Protein ID WP_005543446.1
Coordinates 1505821..1506093 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN94_RS07500 1501083..1501637 + 555 WP_005543432.1 HAD family hydrolase -
LIN94_RS07505 1501805..1503352 + 1548 WP_249852870.1 anthranilate synthase component 1 -
LIN94_RS07510 1503363..1503953 + 591 WP_005543437.1 aminodeoxychorismate/anthranilate synthase component II -
LIN94_RS07515 1504027..1504419 + 393 WP_005543439.1 tautomerase family protein -
LIN94_RS07520 1504431..1505432 + 1002 WP_005567382.1 anthranilate phosphoribosyltransferase -
LIN94_RS07525 1505527..1505805 + 279 WP_005543444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN94_RS07530 1505821..1506093 + 273 WP_005543446.1 HigA family addiction module antitoxin Antitoxin
LIN94_RS07535 1506102..1507528 + 1427 Protein_1457 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF -
LIN94_RS07540 1507983..1508258 + 276 WP_005561117.1 hydrogenase maturation factor HybG -
LIN94_RS07545 1508379..1508756 - 378 WP_005543455.1 hypothetical protein -
LIN94_RS07550 1508731..1508922 - 192 WP_005553960.1 hypothetical protein -
LIN94_RS07555 1509283..1509549 + 267 WP_005543457.1 oxaloacetate decarboxylase subunit gamma -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-79)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10490.95 Da        Isoelectric Point: 9.5983

>T220470 WP_005543444.1 NZ_CP085092:1505527-1505805 [Aggregatibacter actinomycetemcomitans]
MILSFKHKGLEQFFKTGSTAGIQAKHAKKLNLQLATLNNAETPLAMSVPSWNLHKLKGDLQEHWAVTVNGNWRLTFKFEN
GHAEVVDYQDYH

Download         Length: 279 bp

>T220470 NZ_CP117046:c86948-86799 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10138.74 Da        Isoelectric Point: 7.3169

>AT220470 WP_005543446.1 NZ_CP085092:1505821-1506093 [Aggregatibacter actinomycetemcomitans]
MHNPPHPGELLKEYIDGVSVTKVAQKLGVSRVTLSRILNGKASITPEMAVRLSELLNTTTPKLWLGMQADYDLWQIEQQH
AVFNIQPLFN

Download         Length: 273 bp

>AT220470 NZ_CP117046:86992-87053 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X2JU35

Antitoxin

Source ID Structure

References