220468

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1260886..1261532 Replicon chromosome
Accession NZ_CP085092
Organism Aggregatibacter actinomycetemcomitans strain 30R

Toxin (Protein)


Gene name higB Uniprot ID X2JQ23
Locus tag LIN94_RS06415 Protein ID WP_005555126.1
Coordinates 1260886..1261236 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID X2JT85
Locus tag LIN94_RS06420 Protein ID WP_005540827.1
Coordinates 1261233..1261532 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN94_RS06395 1256064..1256309 - 246 WP_005540815.1 YgjV family protein -
LIN94_RS06400 1256499..1257836 - 1338 WP_005567415.1 argininosuccinate synthase -
LIN94_RS06405 1257931..1258758 - 828 WP_005540818.1 hypothetical protein -
LIN94_RS06410 1259115..1260698 + 1584 WP_005567417.1 peptide chain release factor 3 -
LIN94_RS06415 1260886..1261236 + 351 WP_005555126.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN94_RS06420 1261233..1261532 + 300 WP_005540827.1 helix-turn-helix transcriptional regulator Antitoxin
LIN94_RS06425 1261568..1264501 - 2934 WP_014167733.1 bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase -
LIN94_RS06430 1264703..1264930 + 228 WP_005567423.1 hypothetical protein -
LIN94_RS06435 1264923..1265684 + 762 WP_025298334.1 CRISPR-associated endonuclease Cas3'' -
LIN94_RS06440 1266030..1266430 + 401 Protein_1243 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13518.64 Da        Isoelectric Point: 9.9664

>T220468 WP_005555126.1 NZ_CP085092:1260886-1261236 [Aggregatibacter actinomycetemcomitans]
MWAVILTERFETWLNQQPIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRVQHSGRAIRLFFAFDPKRRAI
VLCGGDKGNDKRFYRTMIRIADQELNHYLATMEQTK

Download         Length: 351 bp

>T220468 NZ_CP117039:1323832-1324119 [Vibrio parahaemolyticus]
ATGAAAGTAGTTTGGTCTCCACTAGCGCTTCAGAAGCTAGGTGATGCAGCGGAATTTATTTCTTTGGATAATCCAGCTGC
AGCAGAAAACTGGATAAACGAAGTTTTTGACAAAACTGAACTACTTGGAAGTATGCCTGAAATGGGGCGCTTTGTTCCTG
AAATGCCCAATACTAACTATCGTGAAATCATTTTTGGTCACTATCGTATTATCTATAGCTTAAGCCATGAAATCCGAGTA
CTGACAGTTCGTAATTGCCGTCAAATGTTGTCGGAAGATGACCTGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11342.12 Da        Isoelectric Point: 5.8598

>AT220468 WP_005540827.1 NZ_CP085092:1261233-1261532 [Aggregatibacter actinomycetemcomitans]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRVFQI

Download         Length: 300 bp

>AT220468 NZ_CP117039:1323554-1323835 [Vibrio parahaemolyticus]
ATGAGCCGTATTCATTTCGATCAAGATATTCAGCCGTTATCTGAATTTCGCGCAGGTGTAGCTTCTTACATCAAACAAAT
CAACGAGACTCGCCGTCCATTGGTTATCACACAGCGTGGTAAAGGTGTAGCTGTTGTTCTCGATGTTGCAGAGTATGAAG
CAATGCAAGAGAAGATCGAGTTACTGGAAGAAATGCGCACAGCTGAAGCTCAATTAGCTTCAGGCCTTGGTATTTCAAAT
GATGATGCTCGTTCTCAAGTACTGGGGCGCATTAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X2JQ23

Antitoxin

Source ID Structure
AlphaFold DB X2JT85

References