Detailed information of TA system TA220462

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1505527..1506093
• Replicon: chromosome
• Accession: NZ_CP085091
• Organism: Aggregatibacter actinomycetemcomitans strain 30S

Toxin (Protein)

• Gene name: higB
• Uniprot ID: X2JU35
• Locus tag: LIN93_RS07530
• Protein ID: WP_005543444.1
• Coordinates: 1505527..1505805 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LIN93_RS07535
• Protein ID: WP_005543446.1
• Coordinates: 1505821..1506093 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LIN93_RS07505	1501083..1501637	+	555	WP_005543432.1	HAD family hydrolase	-
LIN93_RS07510	1501805..1503352	+	1548	WP_249852870.1	anthranilate synthase component 1	-
LIN93_RS07515	1503363..1503953	+	591	WP_005543437.1	aminodeoxychorismate/anthranilate synthase component II	-
LIN93_RS07520	1504027..1504419	+	393	WP_005543439.1	tautomerase family protein	-
LIN93_RS07525	1504431..1505432	+	1002	WP_005567382.1	anthranilate phosphoribosyltransferase	-
LIN93_RS07530	1505527..1505805	+	279	WP_005543444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LIN93_RS07535	1505821..1506093	+	273	WP_005543446.1	HigA family addiction module antitoxin	Antitoxin
LIN93_RS07540	1506102..1507528	+	1427	Protein_1458	bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF	-
LIN93_RS07545	1507983..1508258	+	276	WP_005561117.1	hydrogenase maturation factor HybG	-
LIN93_RS07550	1508379..1508756	-	378	WP_005543455.1	hypothetical protein	-
LIN93_RS07555	1508731..1508922	-	192	WP_005553960.1	hypothetical protein	-
LIN93_RS07560	1509283..1509549	+	267	WP_005543457.1	oxaloacetate decarboxylase subunit gamma	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (4-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-79)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10490.95 Da
• Isoelectric Point: 9.5983

>T220462 WP_005543444.1 NZ_CP085091:1505527-1505805 [Aggregatibacter actinomycetemcomitans]
MILSFKHKGLEQFFKTGSTAGIQAKHAKKLNLQLATLNNAETPLAMSVPSWNLHKLKGDLQEHWAVTVNGNWRLTFKFEN
GHAEVVDYQDYH

Nucleotide

• Length: 279 bp

>T220462 NZ_CP117033:4803068-4803379 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10138.74 Da
• Isoelectric Point: 7.3169

>AT220462 WP_005543446.1 NZ_CP085091:1505821-1506093 [Aggregatibacter actinomycetemcomitans]
MHNPPHPGELLKEYIDGVSVTKVAQKLGVSRVTLSRILNGKASITPEMAVRLSELLNTTTPKLWLGMQADYDLWQIEQQH
AVFNIQPLFN

Nucleotide

• Length: 273 bp

>AT220462 NZ_CP117033:4803376-4803822 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Toxin

• AlphaFold DB: X2JU35