Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1495592..1496158 Replicon chromosome
Accession NZ_CP085090
Organism Aggregatibacter actinomycetemcomitans strain 31R

Toxin (Protein)


Gene name higB Uniprot ID X2JU35
Locus tag LIN96_RS07470 Protein ID WP_005543444.1
Coordinates 1495592..1495870 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag LIN96_RS07475 Protein ID WP_005543446.1
Coordinates 1495886..1496158 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIN96_RS07445 1491148..1491702 + 555 WP_005543432.1 HAD family hydrolase -
LIN96_RS07450 1491870..1493417 + 1548 WP_249847443.1 anthranilate synthase component 1 -
LIN96_RS07455 1493428..1494018 + 591 WP_005543437.1 aminodeoxychorismate/anthranilate synthase component II -
LIN96_RS07460 1494092..1494484 + 393 WP_005543439.1 tautomerase family protein -
LIN96_RS07465 1494496..1495497 + 1002 WP_005567382.1 anthranilate phosphoribosyltransferase -
LIN96_RS07470 1495592..1495870 + 279 WP_005543444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIN96_RS07475 1495886..1496158 + 273 WP_005543446.1 HigA family addiction module antitoxin Antitoxin
LIN96_RS07480 1496167..1497593 + 1427 Protein_1447 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF -
LIN96_RS07485 1498048..1498323 + 276 WP_005561117.1 hydrogenase maturation factor HybG -
LIN96_RS07490 1498444..1498821 - 378 WP_005543455.1 hypothetical protein -
LIN96_RS07495 1498796..1498987 - 192 WP_005553960.1 hypothetical protein -
LIN96_RS07500 1499348..1499614 + 267 WP_249847445.1 oxaloacetate decarboxylase subunit gamma -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-79)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10490.95 Da        Isoelectric Point: 9.5983

>T220454 WP_005543444.1 NZ_CP085090:1495592-1495870 [Aggregatibacter actinomycetemcomitans]
MILSFKHKGLEQFFKTGSTAGIQAKHAKKLNLQLATLNNAETPLAMSVPSWNLHKLKGDLQEHWAVTVNGNWRLTFKFEN
GHAEVVDYQDYH

Download         Length: 279 bp

>T220454 NZ_CP117033:2125791-2125894 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10138.74 Da        Isoelectric Point: 7.3169

>AT220454 WP_005543446.1 NZ_CP085090:1495886-1496158 [Aggregatibacter actinomycetemcomitans]
MHNPPHPGELLKEYIDGVSVTKVAQKLGVSRVTLSRILNGKASITPEMAVRLSELLNTTTPKLWLGMQADYDLWQIEQQH
AVFNIQPLFN

Download         Length: 273 bp

>AT220454 NZ_CP117033:c2125896-2125751 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X2JU35

Antitoxin

Source ID Structure

References