220427

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1898447..1898966 Replicon chromosome
Accession NZ_CP085086
Organism Streptococcus suis strain Ssuis_MA6

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag LIO31_RS09450 Protein ID WP_013730620.1
Coordinates 1898447..1898704 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag LIO31_RS09455 Protein ID WP_002939010.1
Coordinates 1898706..1898966 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIO31_RS09435 1894920..1896650 - 1731 WP_226960907.1 hypothetical protein -
LIO31_RS09440 1897013..1897885 - 873 WP_014736465.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
LIO31_RS09445 1897904..1898431 - 528 Protein_1823 DUF1697 domain-containing protein -
LIO31_RS09450 1898447..1898704 - 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
LIO31_RS09455 1898706..1898966 - 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LIO31_RS09460 1899042..1899497 - 456 WP_012028534.1 8-oxo-dGTP diphosphatase -
LIO31_RS09465 1899504..1899833 - 330 WP_012775364.1 type II toxin-antitoxin system RelE/ParE family toxin -
LIO31_RS09470 1899823..1900110 - 288 WP_012028535.1 hypothetical protein -
LIO31_RS09475 1900208..1900576 - 369 WP_023371689.1 hypothetical protein -
LIO31_RS09480 1900569..1901138 - 570 WP_012775700.1 ribonuclease M5 -
LIO31_RS09485 1901122..1901904 - 783 WP_012028536.1 TatD family hydrolase -
LIO31_RS09490 1902011..1902148 - 138 WP_002939016.1 50S ribosomal protein L34 -
LIO31_RS09495 1902316..1903311 - 996 WP_012775367.1 RNA-binding cell elongation regulator Jag/EloR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T220427 WP_013730620.1 NZ_CP085086:c1898704-1898447 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T220427 NZ_CP117020:c1996086-1995751 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT220427 WP_002939010.1 NZ_CP085086:c1898966-1898706 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT220427 NZ_CP117020:c1996334-1996086 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References