Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 344090..344817 Replicon chromosome
Accession NC_009436
Organism Enterobacter sp. 638

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ENT638_RS01570 Protein ID WP_041689584.1
Coordinates 344506..344817 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ENT638_RS01565 Protein ID WP_011915556.1
Coordinates 344090..344509 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ENT638_RS01545 340002..342278 + 2277 WP_011915552.1 response regulator -
ENT638_RS01550 342391..343023 + 633 WP_041689227.1 GNAT family N-acetyltransferase -
ENT638_RS01555 343093..343416 + 324 WP_011915554.1 hypothetical protein -
ENT638_RS01560 343481..343966 - 486 WP_150099546.1 hypothetical protein -
ENT638_RS01565 344090..344509 - 420 WP_011915556.1 helix-turn-helix domain-containing protein Antitoxin
ENT638_RS01570 344506..344817 - 312 WP_041689584.1 type II toxin-antitoxin system HigB family toxin Toxin
ENT638_RS01575 344975..345733 - 759 WP_011915558.1 phosphonate metabolism protein PhnP -
ENT638_RS01580 345743..346177 - 435 WP_011915559.1 aminoalkylphosphonate N-acetyltransferase -
ENT638_RS01585 346164..346721 - 558 WP_150099547.1 ribose 1,5-bisphosphokinase -
ENT638_RS01590 346718..347854 - 1137 WP_011915561.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
ENT638_RS01595 347851..348531 - 681 WP_011915562.1 phosphonate C-P lyase system protein PhnL -
ENT638_RS01600 348541..349296 - 756 WP_011915563.1 phosphonate C-P lyase system protein PhnK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12410.20 Da        Isoelectric Point: 9.5604

>T22037 WP_041689584.1 NC_009436:c344817-344506 [Enterobacter sp. 638]
MHVISKEPFEEAAKHYPNDSLALLALYRLLRETDFVSPTELRTLIPSLDNFKHRNKWWVLDVGGNNLRIVAYINFVNKRF
YVKHIVTHSEYDKLNRYYRENKE

Download         Length: 312 bp

>T22037 NC_009436:c344817-344506 [Enterobacter sp. 638]
ATGCACGTCATTTCGAAAGAGCCTTTTGAGGAAGCGGCAAAGCACTACCCAAACGATTCGTTAGCTCTTCTGGCGTTGTA
CCGCTTACTTCGTGAGACAGATTTTGTTTCACCGACAGAACTGAGAACGTTAATACCGAGTCTGGATAATTTTAAGCATC
GGAATAAATGGTGGGTATTAGATGTGGGGGGCAACAACTTGAGGATTGTCGCTTACATCAATTTTGTGAATAAACGCTTT
TACGTGAAGCATATCGTCACCCACTCTGAATACGATAAGTTGAACCGCTACTACAGGGAGAACAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15476.55 Da        Isoelectric Point: 4.4429

>AT22037 WP_011915556.1 NC_009436:c344509-344090 [Enterobacter sp. 638]
MITDTARAIEATKQLVDAVPFLGGSSSESDYREALALVDYLIEKDDENPLIDFLASKIADYENNSDRFAEFNKSVAEMPV
GVALLRTLIDQYKLSYADLKEEIGSKSLVSQILSGQRSLTITHIKALSARFGVRPEWFL

Download         Length: 420 bp

>AT22037 NC_009436:c344509-344090 [Enterobacter sp. 638]
ATGATCACTGATACCGCAAGAGCCATTGAGGCCACTAAACAACTCGTCGACGCTGTTCCTTTCCTGGGTGGCAGTTCTTC
AGAGAGTGATTATCGCGAAGCCCTGGCGCTGGTGGATTATCTGATCGAGAAAGACGATGAAAATCCCCTGATTGACTTCC
TCGCGAGCAAAATTGCCGACTATGAAAATAATAGCGACCGCTTCGCTGAGTTTAATAAATCTGTCGCTGAAATGCCTGTC
GGCGTTGCTCTGCTGCGCACGCTGATCGATCAGTACAAGCTTTCTTACGCTGATCTGAAAGAAGAGATTGGTTCGAAATC
ACTGGTCAGCCAAATCTTATCCGGACAACGCTCTCTGACCATCACCCACATTAAGGCGCTTTCTGCACGCTTCGGTGTGA
GACCGGAATGGTTCCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References