Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 761767..762460 Replicon chromosome
Accession NZ_CP085074
Organism Escherichia coli strain P21_SE1_04.20

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LH372_RS03685 Protein ID WP_000415584.1
Coordinates 761767..762063 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LH372_RS03690 Protein ID WP_000650107.1
Coordinates 762065..762460 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH372_RS03650 (756855) 756855..757169 - 315 WP_000958598.1 putative quinol monooxygenase -
LH372_RS03655 (757200) 757200..757781 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LH372_RS03660 (758100) 758100..758432 + 333 WP_000917685.1 DUF2645 family protein -
LH372_RS03665 (758478) 758478..759827 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LH372_RS03670 (759824) 759824..760483 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LH372_RS03675 (760635) 760635..761027 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LH372_RS03680 (761080) 761080..761562 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LH372_RS03685 (761767) 761767..762063 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LH372_RS03690 (762065) 762065..762460 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LH372_RS03695 (762593) 762593..764200 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LH372_RS03700 (764338) 764338..766596 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T220358 WP_000415584.1 NZ_CP085074:761767-762063 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T220358 NZ_CP117008:c5000826-5000515 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT220358 WP_000650107.1 NZ_CP085074:762065-762460 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT220358 NZ_CP117008:c5000514-5000224 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References