Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HTH(antitoxin) |
Location | 4773103..4773705 | Replicon | chromosome |
Accession | NZ_CP085069 | ||
Organism | Escherichia coli strain P27_L1_05.20 |
Toxin (Protein)
Gene name | higB | Uniprot ID | U9XIS6 |
Locus tag | LH371_RS22995 | Protein ID | WP_000897305.1 |
Coordinates | 4773394..4773705 (-) | Length | 104 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | LH371_RS22990 | Protein ID | WP_000356397.1 |
Coordinates | 4773103..4773393 (-) | Length | 97 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LH371_RS22965 (4769029) | 4769029..4769931 | + | 903 | WP_000331377.1 | formate dehydrogenase O subunit beta | - |
LH371_RS22970 (4769928) | 4769928..4770563 | + | 636 | WP_000829013.1 | formate dehydrogenase cytochrome b556 subunit | - |
LH371_RS22975 (4770560) | 4770560..4771489 | + | 930 | WP_000027708.1 | formate dehydrogenase accessory protein FdhE | - |
LH371_RS22980 (4771819) | 4771819..4772061 | - | 243 | WP_001086388.1 | protein YiiF | - |
LH371_RS22985 (4772280) | 4772280..4772498 | - | 219 | WP_001295676.1 | CopG family transcriptional regulator | - |
LH371_RS22990 (4773103) | 4773103..4773393 | - | 291 | WP_000356397.1 | NadS family protein | Antitoxin |
LH371_RS22995 (4773394) | 4773394..4773705 | - | 312 | WP_000897305.1 | hypothetical protein | Toxin |
LH371_RS23000 (4773934) | 4773934..4774842 | + | 909 | WP_106474777.1 | alpha/beta hydrolase | - |
LH371_RS23005 (4774906) | 4774906..4775847 | - | 942 | WP_001343389.1 | fatty acid biosynthesis protein FabY | - |
LH371_RS23010 (4775892) | 4775892..4776329 | - | 438 | WP_000560983.1 | D-aminoacyl-tRNA deacylase | - |
LH371_RS23015 (4776326) | 4776326..4777198 | - | 873 | WP_000920762.1 | virulence factor BrkB family protein | - |
LH371_RS23020 (4777192) | 4777192..4777791 | - | 600 | WP_001295269.1 | glucose-1-phosphatase | - |
LH371_RS23025 (4777890) | 4777890..4778675 | - | 786 | WP_000059678.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12190.19 Da Isoelectric Point: 9.7791
>T220348 WP_000897305.1 NZ_CP085069:c4773705-4773394 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW
Download Length: 312 bp
>T220348 NZ_CP117008:3025649-3025756 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10846.43 Da Isoelectric Point: 10.8907
>AT220348 WP_000356397.1 NZ_CP085069:c4773393-4773103 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR
Download Length: 291 bp
>AT220348 NZ_CP117008:c3025602-3025536 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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