Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4051573..4052266 Replicon chromosome
Accession NZ_CP085063
Organism Escherichia coli strain P31_YH1_02.21

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LH370_RS19550 Protein ID WP_000415584.1
Coordinates 4051573..4051869 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LH370_RS19555 Protein ID WP_000650107.1
Coordinates 4051871..4052266 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH370_RS19515 (4046661) 4046661..4046975 - 315 WP_000958598.1 putative quinol monooxygenase -
LH370_RS19520 (4047006) 4047006..4047587 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LH370_RS19525 (4047906) 4047906..4048238 + 333 WP_023149630.1 DUF2645 family protein -
LH370_RS19530 (4048284) 4048284..4049633 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LH370_RS19535 (4049630) 4049630..4050289 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LH370_RS19540 (4050441) 4050441..4050833 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LH370_RS19545 (4050886) 4050886..4051368 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LH370_RS19550 (4051573) 4051573..4051869 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LH370_RS19555 (4051871) 4051871..4052266 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LH370_RS19560 (4052399) 4052399..4054006 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LH370_RS19565 (4054144) 4054144..4056402 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T220313 WP_000415584.1 NZ_CP085063:4051573-4051869 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T220313 NZ_CP117006:1869375-1869626 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT220313 WP_000650107.1 NZ_CP085063:4051871-4052266 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT220313 NZ_CP117006:1869623-1869877 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References