Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3916419..3917112 Replicon chromosome
Accession NZ_CP085060
Organism Escherichia coli strain P30_L1_05.20

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LH369_RS18805 Protein ID WP_000415584.1
Coordinates 3916816..3917112 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LH369_RS18800 Protein ID WP_000650107.1
Coordinates 3916419..3916814 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LH369_RS18790 (3912283) 3912283..3914541 - 2259 WP_032329482.1 DNA topoisomerase IV subunit A -
LH369_RS18795 (3914679) 3914679..3916286 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LH369_RS18800 (3916419) 3916419..3916814 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LH369_RS18805 (3916816) 3916816..3917112 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LH369_RS18810 (3917317) 3917317..3917799 - 483 WP_000183505.1 GyrI-like domain-containing protein -
LH369_RS18815 (3917852) 3917852..3918244 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LH369_RS18820 (3918396) 3918396..3919055 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
LH369_RS18825 (3919052) 3919052..3920401 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LH369_RS18830 (3920447) 3920447..3920779 - 333 WP_000917685.1 DUF2645 family protein -
LH369_RS18835 (3921098) 3921098..3921679 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LH369_RS18840 (3921710) 3921710..3922024 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T220277 WP_000415584.1 NZ_CP085060:c3917112-3916816 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T220277 NZ_CP116996:23502-23882 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTAGCTACGGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGCATACAGGTATATGATTCTCCCGTGCTGGTGGAACTTGCGGTGGGGGCCGCAACTGG
TGAAATCCCCGTATCTTCAGTAGCGGAAAAACTACGTGAATTATTTGGTTCCAATATTTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT220277 WP_000650107.1 NZ_CP085060:c3916814-3916419 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT220277 NZ_CP116996:23281-23502 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGGGGCCGAGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTTGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References