Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 712865..713559 Replicon chromosome
Accession NC_009381
Organism Yersinia pestis Pestoides F

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag YPDSF_RS03295 Protein ID WP_002214787.1
Coordinates 712865..713161 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag YPDSF_RS03300 Protein ID WP_002209924.1
Coordinates 713161..713559 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPDSF_RS03260 707987..709504 + 1518 WP_002209930.1 lysine--tRNA ligase -
YPDSF_RS03270 709937..711151 + 1215 WP_011906175.1 tyrosine-type recombinase/integrase -
YPDSF_RS03275 711233..711418 - 186 WP_002209928.1 hypothetical protein -
YPDSF_RS03285 712016..712276 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPDSF_RS03290 712339..712701 + 363 WP_002209925.1 helix-turn-helix domain-containing protein -
YPDSF_RS03295 712865..713161 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
YPDSF_RS03300 713161..713559 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
YPDSF_RS03305 713959..716250 - 2292 WP_002209923.1 toprim domain-containing protein -
YPDSF_RS03310 716550..716876 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPDSF_RS24415 716869..717021 + 153 WP_002209921.1 hypothetical protein -
YPDSF_RS03320 717035..717235 - 201 WP_002209920.1 AlpA family transcriptional regulator -
YPDSF_RS03325 717417..717749 - 333 WP_002214791.1 hypothetical protein -
YPDSF_RS03330 717755..717991 - 237 WP_002214792.1 hypothetical protein -
YPDSF_RS03335 718004..718369 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T22021 WP_002214787.1 NC_009381:712865-713161 [Yersinia pestis Pestoides F]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T22021 NC_009381:712865-713161 [Yersinia pestis Pestoides F]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT22021 WP_002209924.1 NC_009381:713161-713559 [Yersinia pestis Pestoides F]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT22021 NC_009381:713161-713559 [Yersinia pestis Pestoides F]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References