220160

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 46428..47031 Replicon plasmid pCEP14_01
Accession NZ_CP084922
Organism Acinetobacter pittii strain CEP14

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LG653_RS19310 Protein ID WP_000288004.1
Coordinates 46428..46757 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LG653_RS19315 Protein ID WP_001258993.1
Coordinates 46744..47031 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG653_RS19270 (LG653_19270) 42230..42558 + 329 Protein_38 DUF4236 domain-containing protein -
LG653_RS19275 (LG653_19275) 42800..43312 - 513 WP_000464612.1 Fic family protein -
LG653_RS19280 (LG653_19280) 43315..43500 - 186 WP_000755724.1 hypothetical protein -
LG653_RS19285 (LG653_19285) 43667..44599 + 933 WP_000743263.1 IS5 family transposase -
LG653_RS19290 (LG653_19290) 44730..44927 - 198 WP_025464206.1 hypothetical protein -
LG653_RS19295 (LG653_19295) 45020..45238 - 219 WP_000994925.1 hypothetical protein -
LG653_RS19300 (LG653_19300) 45295..45897 - 603 WP_000096286.1 BRO family protein -
LG653_RS19305 (LG653_19305) 46104..46373 + 270 WP_000453245.1 transcriptional regulator -
LG653_RS19310 (LG653_19310) 46428..46757 + 330 WP_000288004.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LG653_RS19315 (LG653_19315) 46744..47031 + 288 WP_001258993.1 helix-turn-helix transcriptional regulator Antitoxin
LG653_RS19320 (LG653_19320) 47068..47256 - 189 WP_000340067.1 hypothetical protein -
LG653_RS19325 (LG653_19325) 47658..47981 - 324 Protein_49 DUF4236 domain-containing protein -
LG653_RS19330 (LG653_19330) 47990..48166 - 177 WP_002120129.1 hypothetical protein -
LG653_RS19335 (LG653_19335) 48238..48561 - 324 WP_005804845.1 hypothetical protein -
LG653_RS19340 (LG653_19340) 48916..49425 - 510 Protein_52 terminase -
LG653_RS19345 (LG653_19345) 49409..49932 - 524 Protein_53 DUF2280 domain-containing protein -
LG653_RS19350 (LG653_19350) 50023..50664 - 642 WP_000372120.1 putative metallopeptidase -
LG653_RS19355 (LG653_19355) 50633..51094 - 462 WP_000378528.1 hypothetical protein -
LG653_RS19360 (LG653_19360) 51155..51610 - 456 WP_001136766.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95483 95483
- flank IS/Tn - - 43667..44599 932


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-90)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12571.69 Da        Isoelectric Point: 8.8102

>T220160 WP_000288004.1 NZ_CP084922:46428-46757 [Acinetobacter pittii]
MYTIEYYSEDVQDEILTLPDGLLARYFNLTDRMVIYGANLGEPHTLPMSKGLFELRLKSQEGIARVMYCTLVGKRIVMLH
SFVKKTQKTPKQDLNLALDRMKEVKNANT

Download         Length: 330 bp

>T220160 NZ_CP116970:3267312-3267623 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10565.30 Da        Isoelectric Point: 10.1453

>AT220160 WP_001258993.1 NZ_CP084922:46744-47031 [Acinetobacter pittii]
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTARRDAGLSQAQIAERMGTSVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV

Download         Length: 288 bp

>AT220160 NZ_CP116970:3267624-3267914 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References