Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 11889..12540 Replicon plasmid pCEP14_01
Accession NZ_CP084922
Organism Acinetobacter pittii strain CEP14

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LG653_RS19160 Protein ID WP_000269910.1
Coordinates 11889..12197 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LG653_RS19165 Protein ID WP_001140619.1
Coordinates 12238..12540 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LG653_RS19125 (LG653_19125) 7108..7197 + 90 Protein_9 DNA-binding protein -
LG653_RS19130 (LG653_19130) 7514..8032 + 519 WP_000447196.1 tetratricopeptide repeat protein -
LG653_RS19135 (LG653_19135) 8164..8676 + 513 WP_001089570.1 SMI1/KNR4 family protein -
LG653_RS19140 (LG653_19140) 8884..9786 + 903 WP_000466974.1 hypothetical protein -
LG653_RS19145 (LG653_19145) 10043..10288 + 246 WP_000246757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LG653_RS19150 (LG653_19150) 10278..10571 + 294 WP_000221360.1 type II toxin-antitoxin system RelE/ParE family toxin -
LG653_RS19155 (LG653_19155) 10758..10874 + 117 Protein_15 IS5/IS1182 family transposase -
LG653_RS19160 (LG653_19160) 11889..12197 + 309 WP_000269910.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LG653_RS19165 (LG653_19165) 12238..12540 + 303 WP_001140619.1 XRE family transcriptional regulator Antitoxin
LG653_RS19170 (LG653_19170) 12533..12742 + 210 WP_000069470.1 hypothetical protein -
LG653_RS19175 (LG653_19175) 12852..13079 - 228 WP_000555567.1 hypothetical protein -
LG653_RS19180 (LG653_19180) 13845..14148 - 304 Protein_20 XRE family transcriptional regulator -
LG653_RS19185 (LG653_19185) 14141..14497 - 357 WP_000269908.1 type II toxin-antitoxin system RelE/ParE family toxin -
LG653_RS19190 (LG653_19190) 15055..15738 + 684 WP_000478902.1 hypothetical protein -
LG653_RS19195 (LG653_19195) 15943..16471 + 529 Protein_23 IS3 family transposase -
LG653_RS19200 (LG653_19200) 16714..17034 + 321 WP_001081101.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..95483 95483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-102)

Antitoxin

HigA2-like, helix-turn-helix domain

(13-89)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11742.64 Da        Isoelectric Point: 9.0002

>T220159 WP_000269910.1 NZ_CP084922:11889-12197 [Acinetobacter pittii]
MWTVITTDLFNEWLVQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIAD

Download         Length: 309 bp

>T220159 NZ_CP116970:c2798435-2798160 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11206.01 Da        Isoelectric Point: 6.7282

>AT220159 WP_001140619.1 NZ_CP084922:12238-12540 [Acinetobacter pittii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT220159 NZ_CP116970:c2798163-2797804 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCTAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References