Detailed information of TA system TA220154

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe(toxin)
• Location: 1844770..1845266
• Replicon: chromosome
• Accession: NZ_CP084916
• Organism: Carnobacterium viridans strain AB01

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LHA31_RS09180
• Protein ID: WP_035020327.1
• Coordinates: 1844770..1845036 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A1H0Z955
• Locus tag: LHA31_RS09185
• Protein ID: WP_035020325.1
• Coordinates: 1845021..1845266 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHA31_RS09150 (LHA31_09150)	1839963..1840235	+	273	WP_089976485.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LHA31_RS09155 (LHA31_09155)	1840745..1840960	+	216	WP_035020336.1	hypothetical protein	-
LHA31_RS09160 (LHA31_09160)	1841066..1841788	-	723	WP_089976481.1	MerR family transcriptional regulator	-
LHA31_RS09165 (LHA31_09165)	1841792..1842601	-	810	WP_035020334.1	Hsp33 family molecular chaperone HslO	-
LHA31_RS09170 (LHA31_09170)	1843015..1843413	-	399	WP_035020332.1	hypothetical protein	-
LHA31_RS09175 (LHA31_09175)	1843430..1843867	-	438	WP_035020331.1	LytTR family DNA-binding domain-containing protein	-
LHA31_RS09180 (LHA31_09180)	1844770..1845036	-	267	WP_035020327.1	Txe/YoeB family addiction module toxin	Toxin
LHA31_RS09185 (LHA31_09185)	1845021..1845266	-	246	WP_035020325.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LHA31_RS09190 (LHA31_09190)	1845379..1845714	-	336	WP_226776571.1	hypothetical protein	-
LHA31_RS09195 (LHA31_09195)	1845938..1846216	+	279	WP_035020323.1	DUF1905 domain-containing protein	-
LHA31_RS09200 (LHA31_09200)	1846317..1847495	-	1179	WP_035020322.1	IS256 family transposase	-
LHA31_RS09205 (LHA31_09205)	1847669..1848151	+	483	Protein_1766	tyrosine-type recombinase/integrase	-
LHA31_RS09210 (LHA31_09210)	1848574..1848828	-	255	WP_035020320.1	hypothetical protein	-
LHA31_RS09215 (LHA31_09215)	1849525..1849668	+	144	WP_226776572.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1846317..1847495	1178

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10389.15 Da
• Isoelectric Point: 10.1296

>T220154 WP_035020327.1 NZ_CP084916:c1845036-1844770 [Carnobacterium viridans]
MGYSIKLAKSMMKDLENLKSAPLEQKFKGIIEVLKENPFQNPPPYVKLVRNLKDKYSRRLNIQHRVVCSVDNDAKEVIIW
SAWTHYER

Nucleotide

• Length: 267 bp

>T220154 NZ_CP116970:c1731685-1731287 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9266.40 Da
• Isoelectric Point: 4.3455

>AT220154 WP_035020325.1 NZ_CP084916:c1845266-1845021 [Carnobacterium viridans]
VSIVNPSQAREAFYQLLKDVNKTTEPVYISGKNEAVMISKKDWYAIQETLYIQSYGVAGVIHQREQANEFVAVEDIDWDT
L

Nucleotide

• Length: 246 bp

>AT220154 NZ_CP116970:c1731912-1731685 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1H0Z955