220103

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3945233..3945455 Replicon chromosome
Accession NZ_CP084899
Organism Escherichia coli strain W3110-P

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag LHV60_RS19180 Protein ID WP_000141634.1
Coordinates 3945348..3945455 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3945233..3945299 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHV60_RS19160 3940674..3941576 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
LHV60_RS19165 3941587..3942570 + 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
LHV60_RS19170 3942567..3943571 + 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
LHV60_RS19175 3943601..3944872 - 1272 WP_001295225.1 aromatic amino acid transport family protein -
- 3945233..3945299 - 67 - - Antitoxin
LHV60_RS19180 3945348..3945455 + 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
LHV60_RS19185 3945542..3947221 - 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
LHV60_RS19190 3947218..3947409 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
LHV60_RS19195 3947406..3948977 - 1572 WP_001204931.1 cellulose biosynthesis c-di-GMP-binding protein BcsE -
LHV60_RS19200 3949250..3949438 + 189 WP_001063318.1 cellulose biosynthesis protein BcsR -
LHV60_RS19205 3949474..3950202 + 729 WP_011310329.1 cellulose biosynthesis protein BcsQ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-35)


Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T220103 WP_000141634.1 NZ_CP084899:3945348-3945455 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T220103 NZ_CP116931:910586-910993 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 67 bp

>AT220103 NZ_CP084899:c3945299-3945233 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 5LBJ


Antitoxin

Download structure file

References