Detailed information of TA system TA220060

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3945233..3945455
• Replicon: chromosome
• Accession: NZ_CP084898
• Organism: Escherichia coli strain gw25

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: LHV65_RS19180
• Protein ID: WP_000141634.1
• Coordinates: 3945348..3945455 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3945233..3945299 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LHV65_RS19160	3940674..3941576	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
LHV65_RS19165	3941587..3942570	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
LHV65_RS19170	3942567..3943571	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
LHV65_RS19175	3943601..3944872	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	3945233..3945299	-	67	-	-	Antitoxin
LHV65_RS19180	3945348..3945455	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
LHV65_RS19185	3945542..3947221	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
LHV65_RS19190	3947218..3947409	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
LHV65_RS19195	3947406..3948977	-	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
LHV65_RS19200	3949250..3949438	+	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
LHV65_RS19205	3949474..3950202	+	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T220060 WP_000141634.1 NZ_CP084898:3945348-3945455 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T220060 NZ_CP116925:c740386-740009 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGATCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT220060 NZ_CP084898:c3945299-3945233 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin