Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1414434..1414805 | Replicon | chromosome |
| Accession | NZ_CP084896 | ||
| Organism | Escherichia coli strain g62 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | F4VC37 |
| Locus tag | LHV62_RS06985 | Protein ID | WP_001317028.1 |
| Coordinates | 1414611..1414805 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1414434..1414612 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LHV62_RS06960 (1410389) | 1410389..1411762 | + | 1374 | WP_000123737.1 | ATP-dependent RNA helicase DbpA | - |
| LHV62_RS06965 (1411891) | 1411891..1412826 | - | 936 | WP_001157406.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| LHV62_RS06970 (1412878) | 1412878..1414113 | - | 1236 | WP_000040852.1 | site-specific integrase | - |
| LHV62_RS06975 (1414115) | 1414115..1414330 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1414434) | 1414434..1414612 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1414434) | 1414434..1414612 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1414434) | 1414434..1414612 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1414434) | 1414434..1414612 | + | 179 | NuclAT_0 | - | Antitoxin |
| LHV62_RS06980 (1414409) | 1414409..1414618 | - | 210 | WP_000276809.1 | double-strand break reduction protein RcbA | - |
| LHV62_RS06985 (1414611) | 1414611..1414805 | - | 195 | WP_001317028.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| LHV62_RS06990 (1414862) | 1414862..1415671 | - | 810 | WP_000166319.1 | recombination protein RecT | - |
| LHV62_RS06995 (1415664) | 1415664..1418264 | - | 2601 | WP_000105143.1 | exodeoxyribonuclease VIII | - |
| LHV62_RS07000 (1418366) | 1418366..1418641 | - | 276 | WP_000632297.1 | protein RacC | - |
| LHV62_RS07005 (1418716) | 1418716..1418886 | - | 171 | WP_001352098.1 | YdaE family protein | - |
| LHV62_RS07010 (1418886) | 1418886..1419107 | - | 222 | WP_000560225.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1381699..1434552 | 52853 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7018.89 Da Isoelectric Point: 8.9538
>T219950 WP_001317028.1 NZ_CP084896:c1414805-1414611 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T219950 NZ_CP116901:50775-50909 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA
Antitoxin
Download Length: 179 bp
>AT219950 NZ_CP084896:1414434-1414612 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
