Detailed information of TA system TA219808

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2557306..2557490
• Replicon: chromosome
• Accession: NZ_CP084892
• Organism: Staphylococcus aureus strain CC1956/ST4614-MSSA

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: LB315_RS12970
• Protein ID: WP_000482647.1
• Coordinates: 2557383..2557490 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2557306..2557366 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LB315_RS12955	2552760..2552915	-	156	WP_229374842.1	hypothetical protein	-
LB315_RS12960	2553158..2554891	-	1734	WP_229373971.1	ABC transporter ATP-binding protein	-
LB315_RS12965	2554916..2556679	-	1764	WP_229373972.1	ABC transporter ATP-binding protein	-
-	2557306..2557366	+	61	-	-	Antitoxin
LB315_RS12970	2557383..2557490	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
LB315_RS12975	2557624..2558010	-	387	WP_000779353.1	flippase GtxA	-
LB315_RS12980	2558278..2559420	+	1143	WP_001176863.1	glycerate kinase	-
LB315_RS12985	2559480..2560139	+	660	WP_000831298.1	membrane protein	-
LB315_RS12990	2560322..2561533	+	1212	WP_001191927.1	multidrug effflux MFS transporter	-
LB315_RS12995	2561656..2562129	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sbi / hlgA / hlgC / hlgB / hlgB	2535303..2558010	22707

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T219808 WP_000482647.1 NZ_CP084892:c2557490-2557383 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T219808 NZ_CP116720:2009853-2010440 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGAGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT219808 NZ_CP084892:2557306-2557366 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin