Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2531933..2532450 Replicon chromosome
Accession NZ_CP084892
Organism Staphylococcus aureus strain CC1956/ST4614-MSSA

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag LB315_RS12835 Protein ID WP_000113263.1
Coordinates 2531933..2532199 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag LB315_RS12840 Protein ID WP_000584499.1
Coordinates 2532199..2532450 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LB315_RS12810 (2527138) 2527138..2527674 - 537 WP_229373961.1 GNAT family N-acetyltransferase -
LB315_RS12815 (2528143) 2528143..2528967 - 825 WP_000594640.1 formate/nitrite transporter family protein -
LB315_RS12820 (2529170) 2529170..2529352 - 183 WP_000079140.1 hypothetical protein -
LB315_RS12825 (2529439) 2529439..2529906 - 468 WP_000153340.1 SRPBCC domain-containing protein -
LB315_RS12830 (2530092) 2530092..2531639 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
LB315_RS12835 (2531933) 2531933..2532199 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
LB315_RS12840 (2532199) 2532199..2532450 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LB315_RS12845 (2532614) 2532614..2532714 - 101 Protein_2489 hypothetical protein -
LB315_RS12850 (2532721) 2532721..2533320 - 600 WP_103204748.1 DsbA family protein -
LB315_RS12855 (2533339) 2533339..2533701 - 363 WP_000819846.1 DUF4467 domain-containing protein -
LB315_RS12860 (2533956) 2533956..2535206 + 1251 WP_103204749.1 FemA/FemB family glycyltransferase FmhA -
LB315_RS12865 (2535303) 2535303..2536034 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
LB315_RS12870 (2536031) 2536031..2536750 - 720 WP_229373962.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T219807 WP_000113263.1 NZ_CP084892:c2532199-2531933 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T219807 NZ_CP116720:c161920-161639 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT219807 WP_000584499.1 NZ_CP084892:c2532450-2532199 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT219807 NZ_CP116720:c162144-161917 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References