Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Tad-HTH_37 |
| Location | 1485314..1485842 | Replicon | chromosome |
| Accession | NZ_CP084879 | ||
| Organism | Shigella flexneri strain CMCC51574 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | LGV73_RS07565 | Protein ID | WP_005061113.1 |
| Coordinates | 1485314..1485544 (+) | Length | 77 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | Q32DW6 |
| Locus tag | LGV73_RS07570 | Protein ID | WP_000147081.1 |
| Coordinates | 1485534..1485842 (+) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGV73_RS07525 (1480382) | 1480382..1480582 | - | 201 | WP_000111769.1 | protein ninH | - |
| LGV73_RS07530 (1480677) | 1480677..1480934 | - | 258 | WP_001064799.1 | hypothetical protein | - |
| LGV73_RS07535 (1480931) | 1480931..1482322 | - | 1392 | WP_000211324.1 | replicative DNA helicase | - |
| LGV73_RS07540 (1482319) | 1482319..1483197 | - | 879 | WP_000988183.1 | ATP-binding protein | - |
| LGV73_RS07545 (1483208) | 1483208..1484116 | - | 909 | WP_001247840.1 | hypothetical protein | - |
| LGV73_RS07550 (1484103) | 1484103..1484336 | - | 234 | WP_000618004.1 | hypothetical protein | - |
| LGV73_RS07555 (1484333) | 1484333..1484785 | - | 453 | WP_232046050.1 | Rha family transcriptional regulator | - |
| LGV73_RS07560 (1484843) | 1484843..1485301 | - | 459 | WP_000961311.1 | ash family protein | - |
| LGV73_RS07565 (1485314) | 1485314..1485544 | + | 231 | WP_005061113.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LGV73_RS07570 (1485534) | 1485534..1485842 | + | 309 | WP_000147081.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| LGV73_RS07575 (1485884) | 1485884..1486060 | - | 177 | WP_024260406.1 | NinE family protein | - |
| LGV73_RS07580 (1486057) | 1486057..1486467 | - | 411 | WP_000814621.1 | recombination protein NinB | - |
| LGV73_RS07585 (1486464) | 1486464..1486742 | - | 279 | WP_005061104.1 | hypothetical protein | - |
| LGV73_RS07590 (1486817) | 1486817..1487584 | - | 768 | Protein_1475 | hypothetical protein | - |
| LGV73_RS07600 (1489134) | 1489134..1489688 | - | 555 | Protein_1477 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1464212..1516896 | 52684 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 77 a.a. Molecular weight: 8665.12 Da Isoelectric Point: 10.5308
>T219778 WP_005061113.1 NZ_CP084879:1485314-1485544 [Shigella flexneri]
MKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIMLHSFVKKAQKTPPAERKKAETRMKEVKHDW
MKVYGSNLGEPHTSAFGDGLFELRIKGNDGIARVFYCTLTGKRIIMLHSFVKKAQKTPPAERKKAETRMKEVKHDW
Download Length: 231 bp
>T219778 NZ_CP116702:300756-301253 [Agrobacterium fabacearum]
GTGACTCTCAGCGCACCAGTCCCCCTGGCCGATCATCACGAACTGGCCGAATTCAATTCTGGAGTACCTGAACTGGACGA
CTGGCTTCGGCGCCGTGCCCGGGCCAATCAAGCAGGCGGCGCGTCGCGGACCTTTGTCGTTTGCGACGAGAGCCGCGTCA
TCGCGTACTACGCCCTGGCCTCTGGCTCCGTGAAACCGCCGGAAGTGCCTGGTCGCTTTCGGCGCAATATGCCTGATCCA
ATCCCAGTTGCAGTGCTTGGCCGCCTCGCCATTGATCAATCCTGTCAAGGGCGTGGTATCGGCAGGGCATTGGTGCGCGA
CGCGGGTTTGCGCCTGCTGAATGCCGCTGAAGTGCTCGGGATCCGCGGCGTGCTGGTCCATGCGATTTCTGATGACGCAC
GAGCCTTCTACGAAGCCGTCGGCTTCCTGTCTTCTCCGTCCGATCCCATGATGCTGATGGTCGGTTTGCACGACCTCAAT
AACGCGCTGAACACCTAA
GTGACTCTCAGCGCACCAGTCCCCCTGGCCGATCATCACGAACTGGCCGAATTCAATTCTGGAGTACCTGAACTGGACGA
CTGGCTTCGGCGCCGTGCCCGGGCCAATCAAGCAGGCGGCGCGTCGCGGACCTTTGTCGTTTGCGACGAGAGCCGCGTCA
TCGCGTACTACGCCCTGGCCTCTGGCTCCGTGAAACCGCCGGAAGTGCCTGGTCGCTTTCGGCGCAATATGCCTGATCCA
ATCCCAGTTGCAGTGCTTGGCCGCCTCGCCATTGATCAATCCTGTCAAGGGCGTGGTATCGGCAGGGCATTGGTGCGCGA
CGCGGGTTTGCGCCTGCTGAATGCCGCTGAAGTGCTCGGGATCCGCGGCGTGCTGGTCCATGCGATTTCTGATGACGCAC
GAGCCTTCTACGAAGCCGTCGGCTTCCTGTCTTCTCCGTCCGATCCCATGATGCTGATGGTCGGTTTGCACGACCTCAAT
AACGCGCTGAACACCTAA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11185.94 Da Isoelectric Point: 8.5840
>AT219778 WP_000147081.1 NZ_CP084879:1485534-1485842 [Shigella flexneri]
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV
MTGKRTLPTMTHDEMAAKWMEDPAFKAEYDAIADEFALLDEMLAARKEAGLTQAEVAERMGTKATAITRMESNLASGISG
PSFATLKKFARATGKKLQIRFV
Download Length: 309 bp
>AT219778 NZ_CP116702:300463-300759 [Agrobacterium fabacearum]
ATGCCGACCTCACACACGGGTAAGAGCCCGGACGCAAGTGTGCCGCTGAATATGCGCATCAAACCTGCTACTCGCAACTT
GATCGATCGCGCCGCGGAGTTGCTCGGCAAAACGCGCACAGATTTCATGTTGGAAGCTTCCGAGCGCCGTGCGGAGGAGG
TGCTGCTCGACCGTACAATCGTCACGGTAAGCCCCGAAATTTATGCCGAATATCTTGCCCGTCTCGATGCGCCTGCACAG
CCCAATGAGCGTCTAAAGCGCACGATGTCGACCAAAGCGCCCTGGGATGAGGCGTGA
ATGCCGACCTCACACACGGGTAAGAGCCCGGACGCAAGTGTGCCGCTGAATATGCGCATCAAACCTGCTACTCGCAACTT
GATCGATCGCGCCGCGGAGTTGCTCGGCAAAACGCGCACAGATTTCATGTTGGAAGCTTCCGAGCGCCGTGCGGAGGAGG
TGCTGCTCGACCGTACAATCGTCACGGTAAGCCCCGAAATTTATGCCGAATATCTTGCCCGTCTCGATGCGCCTGCACAG
CCCAATGAGCGTCTAAAGCGCACGATGTCGACCAAAGCGCCCTGGGATGAGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|