Detailed information of TA system TA219771

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2402297..2402481
• Replicon: chromosome
• Accession: NZ_CP084878
• Organism: Staphylococcus aureus strain GS426

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: LD199_RS11820
• Protein ID: WP_000482652.1
• Coordinates: 2402374..2402481 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2402297..2402357 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LD199_RS11805 (LD199_11805)	2397808..2397939	-	132	WP_223197975.1	hypothetical protein	-
LD199_RS11810 (LD199_11810)	2398206..2399939	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
LD199_RS11815 (LD199_11815)	2399964..2401727	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	2402297..2402357	+	61	-	-	Antitoxin
LD199_RS11820 (LD199_11820)	2402374..2402481	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
LD199_RS11825 (LD199_11825)	2402615..2403001	-	387	WP_000779360.1	flippase GtxA	-
LD199_RS11830 (LD199_11830)	2403269..2404411	+	1143	WP_001176863.1	glycerate kinase	-
LD199_RS11835 (LD199_11835)	2404471..2405130	+	660	WP_226566070.1	hypothetical protein	-
LD199_RS11840 (LD199_11840)	2405312..2406523	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
LD199_RS11845 (LD199_11845)	2406646..2407119	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T219771 WP_000482652.1 NZ_CP084878:c2402481-2402374 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T219771 NZ_CP116698:167430-167927 [Agrobacterium fabacearum]
GTGACTCTCAGCGCACCAATCCCCCTGGCCGATCATCACGAACTGGCCGAATTCAATTCTGGAGTACCTGAACTGGACGA
CTGGCTTCGGCGCCGTGCCCGGGCCAATCAAGCAGGCGGCGCGTCGCGGACCTTTGTCGTGTGCGACGAGAGCCGCGTCA
TCGCGTACTACGCCCTGGCCTCTGGCTCCGTGAAACCGCCGGAAGTGCCTGGTCGCTTTCGGCGCAATATGCCTGATCCA
ATCCCAGTTGCAGTGCTTGGCCGCCTCGCCATTGATCAATCCTGTCAAGGGCGTGGTATCGGCAGGGCATTGGTGCGCGA
CGCGGGTTTGCGCCTGCTGAATGCCGCTGAAGTGCTCGGGATCCGCGGCGTGCTGGTCCATGCGATTTCTGATGACGCAC
GAGCCTTCTACGAAGCCGTCGGCTTCCTGTCTTCTCCGTCCGATCCCATGATGCTGATGGTCGGTTTGCACGACCTCAAT
AACGCGCTGAACACCTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT219771 NZ_CP084878:2402297-2402357 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin