Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2376858..2377375 | Replicon | chromosome |
| Accession | NZ_CP084878 | ||
| Organism | Staphylococcus aureus strain GS426 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | LD199_RS11685 | Protein ID | WP_000113265.1 |
| Coordinates | 2376858..2377124 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | LD199_RS11690 | Protein ID | WP_000584499.1 |
| Coordinates | 2377124..2377375 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LD199_RS11655 (LD199_11655) | 2372286..2372822 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| LD199_RS11660 (LD199_11660) | 2373056..2373880 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| LD199_RS11665 (LD199_11665) | 2374097..2374279 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| LD199_RS11670 (LD199_11670) | 2374363..2374830 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| LD199_RS11675 (LD199_11675) | 2375016..2376563 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| LD199_RS11680 (LD199_11680) | 2376752..2376823 | - | 72 | Protein_2259 | hypothetical protein | - |
| LD199_RS11685 (LD199_11685) | 2376858..2377124 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| LD199_RS11690 (LD199_11690) | 2377124..2377375 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LD199_RS11695 (LD199_11695) | 2377540..2377620 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| LD199_RS11700 (LD199_11700) | 2377648..2378247 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| LD199_RS11705 (LD199_11705) | 2378266..2378628 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| LD199_RS11710 (LD199_11710) | 2378883..2380133 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| LD199_RS11715 (LD199_11715) | 2380230..2380961 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| LD199_RS11720 (LD199_11720) | 2380958..2381677 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T219770 WP_000113265.1 NZ_CP084878:c2377124-2376858 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T219770 NZ_CP116698:154861-155280 [Agrobacterium fabacearum]
ATGATCTTGCTTGACACCAACGTCATATCCGAACCTTGGAAACCGGTTCCGGACGAGGCGGTGATTGCCTGGTTGGACGC
CCAAGCTGTCGAAACGCTGTTCATCTCCGCAATAACGATTGCGGAACTTCGCTTCGGAATAGCTGCTATGCCTTCAGGCA
GACGGCAAACTATCCTCCGCGACCGTCTCGAGGGCGAGGTGCTGCCACACTTTTCCGGCCGCATCCTGTCCTTCGATCTG
ACTACTTCTCAGTTCTACTCTGAACTGATGGCACGCGCTCGAGCGTCTGGGAAAGCAATCGGCACGGCCGATGGCTACAT
TGCAGCCACAGCGGCAGCAAATGGCCTCACGATCTCAACTCGCGATACAAGCCCTTTCGAGGCTGCCGGGGTGAAAGTGA
TCAACCCCTGGTCCAGATAA
ATGATCTTGCTTGACACCAACGTCATATCCGAACCTTGGAAACCGGTTCCGGACGAGGCGGTGATTGCCTGGTTGGACGC
CCAAGCTGTCGAAACGCTGTTCATCTCCGCAATAACGATTGCGGAACTTCGCTTCGGAATAGCTGCTATGCCTTCAGGCA
GACGGCAAACTATCCTCCGCGACCGTCTCGAGGGCGAGGTGCTGCCACACTTTTCCGGCCGCATCCTGTCCTTCGATCTG
ACTACTTCTCAGTTCTACTCTGAACTGATGGCACGCGCTCGAGCGTCTGGGAAAGCAATCGGCACGGCCGATGGCTACAT
TGCAGCCACAGCGGCAGCAAATGGCCTCACGATCTCAACTCGCGATACAAGCCCTTTCGAGGCTGCCGGGGTGAAAGTGA
TCAACCCCTGGTCCAGATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT219770 WP_000584499.1 NZ_CP084878:c2377375-2377124 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT219770 NZ_CP116698:154610-154864 [Agrobacterium fabacearum]
ATGCCGGCGGTCACCATTCGTAACCTTTCTGAAGAAACACATCGCGCTCTGAGGGTGCGAGCGGCTCATCATGGCCGGAG
CACGGAGGCCGAGATTCGTGCCATTATTGAAGCGGCTGTTCGTCCTCCGGAACGTATTCAGCTCGGTTCCTTGCTCGCGG
CCATTGGTCGCGACGCCGAGCTTTCCAACAGCGACGTTGAAGCTCTTCAGAAAAGTCGCGACAAGACACCTGCTAAGCCG
ATGACCTTCGAATGA
ATGCCGGCGGTCACCATTCGTAACCTTTCTGAAGAAACACATCGCGCTCTGAGGGTGCGAGCGGCTCATCATGGCCGGAG
CACGGAGGCCGAGATTCGTGCCATTATTGAAGCGGCTGTTCGTCCTCCGGAACGTATTCAGCTCGGTTCCTTGCTCGCGG
CCATTGGTCGCGACGCCGAGCTTTCCAACAGCGACGTTGAAGCTCTTCAGAAAAGTCGCGACAAGACACCTGCTAAGCCG
ATGACCTTCGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|