Detailed information of TA system TA219761

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 526587..526865
• Replicon: chromosome
• Accession: NZ_CP084878
• Organism: Staphylococcus aureus strain GS426

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: LD199_RS02440
• Protein ID: WP_001802298.1
• Coordinates: 526587..526691 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	526687..526865 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LD199_RS02425 (LD199_02425)	523384..524166	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
LD199_RS02430 (LD199_02430)	524234..525091	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
LD199_RS02435 (LD199_02435)	525749..525907	-	159	WP_226566097.1	integrase	-
LD199_RS02440 (LD199_02440)	526587..526691	+	105	WP_001802298.1	hypothetical protein	Toxin
-	526687..526865	-	179	-	-	Antitoxin
LD199_RS02450 (LD199_02450)	527124..528215	-	1092	WP_000495669.1	hypothetical protein	-
LD199_RS02455 (LD199_02455)	528481..529458	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
LD199_RS02460 (LD199_02460)	529460..529780	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
LD199_RS02465 (LD199_02465)	529932..530597	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T219761 WP_001802298.1 NZ_CP084878:526587-526691 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T219761 NZ_CP116688:2098016-2098303 [Agrobacterium tumefaciens]
ATCCGGGAAACAAATGAGTTTGCCGATTGGCTTGCCGGCCTGCGCGACGTACAGGCGCGCGCCCGTATTGCACGGCGTAT
TTACCGGCTGGCAGATGGCAATCCCGGAGACGTGAAACCGGTTGGCGAAGGCGTCAGCGAACTCAGGATCGATCTTGGCC
CCGGATATAGGGTCTATTTCGTCCGGCAAGGTGATGTCGTCATCATATTGCTCTGTGGCGGCGACAAGTCATCCCAGTCC
CGCGACATCGCCAAAGCCAGGAGAATGGCGAGAGCGCTCAAGGAGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT219761 NZ_CP084878:c526865-526687 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin