Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2363261..2363950 Replicon chromosome
Accession NZ_CP084874
Organism Klebsiella africana strain 200023

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LGL98_RS11540 Protein ID WP_136032726.1
Coordinates 2363261..2363578 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LGL98_RS11545 Protein ID WP_004180116.1
Coordinates 2363654..2363950 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL98_RS11520 (LGL98_11520) 2359550..2360746 - 1197 WP_136032717.1 L-talarate/galactarate dehydratase -
LGL98_RS11525 (LGL98_11525) 2361051..2362055 + 1005 WP_136032719.1 LacI family DNA-binding transcriptional regulator -
LGL98_RS11530 (LGL98_11530) 2362139..2362756 + 618 WP_136032722.1 glutathione S-transferase family protein -
LGL98_RS11535 (LGL98_11535) 2362827..2363054 + 228 WP_136032724.1 tautomerase PptA -
LGL98_RS11540 (LGL98_11540) 2363261..2363578 + 318 WP_136032726.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGL98_RS11545 (LGL98_11545) 2363654..2363950 + 297 WP_004180116.1 NadS family protein Antitoxin
LGL98_RS11550 (LGL98_11550) 2364029..2364475 + 447 WP_136032728.1 hypothetical protein -
LGL98_RS11555 (LGL98_11555) 2364516..2366132 - 1617 WP_136032729.1 carbohydrate porin -
LGL98_RS11560 (LGL98_11560) 2366176..2367558 - 1383 WP_136032731.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-76)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12205.05 Da        Isoelectric Point: 10.2217

>T219740 WP_136032726.1 NZ_CP084874:2363261-2363578 [Klebsiella africana]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLAPI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

>T219740 NZ_CP116678:49023-49421 [Edwardsiella tarda]
ATGCTGAAATACATGCTGGATACCAACATTTGCATCTTCACACTGAAAAACAGACCCGCCCAGGTTCGAGAGAAATTTAA
CCTGCACCATAATCAGATGTGTATTAGCGCAATTACCTTGATGGAGCTGATCTATGGTGCGGAGAAAAGCCAAGCCCCTG
AGCGTAATCTGGCGGTTATTGAAGGAGTTATTGCTCGCTTGACGGTATTGAACTACGACGTACCGGCAGCCGCTCACTCT
GGCCAGCTGCGTGCAGAGCAAGCCAGACAGGGTCAACCGATTGGCCCTTATGATCAGATGATCGCAGGCCACGCTCGTAG
CCAGGGACTGATCCTCGTCACCAATAACACTCGTGAATTTGCGCGTGTCTCCGGGCTGAGGATTGAAGACTGGGTATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11038.87 Da        Isoelectric Point: 7.3197

>AT219740 WP_004180116.1 NZ_CP084874:2363654-2363950 [Klebsiella africana]
MKDELFADLLASAEEMVRIEKGEQMPKEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp

>AT219740 NZ_CP116678:48796-49023 [Edwardsiella tarda]
ATGGAAACGACTGTTTTTCTCAGTAACCGCAGCCAGGCTGTCAGATTGCCAAAGGCCGTTGCATTACCCGGTGATGTCAA
ACGAGTCGATGTGGTTGCCGTTGGACGAACCCGTATTATTACGCCCGCAGGCGAGTCTTGGGATAGCTGGTTTGAGGGTG
AAAGCGTCAGCGCGGATTTTATGGCTAGCAGAGAGCAGCCACTGGAACAGGAGCGTGAGGATTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References