Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 360229..360875 Replicon chromosome
Accession NZ_CP084874
Organism Klebsiella africana strain 200023

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LGL98_RS01640 Protein ID WP_136033730.1
Coordinates 360229..360576 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LGL98_RS01645 Protein ID WP_136033728.1
Coordinates 360576..360875 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL98_RS01630 (LGL98_01630) 356116..357549 + 1434 WP_004202133.1 glycogen synthase GlgA -
LGL98_RS01635 (LGL98_01635) 357567..360014 + 2448 WP_025710771.1 glycogen phosphorylase -
LGL98_RS01640 (LGL98_01640) 360229..360576 + 348 WP_136033730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGL98_RS01645 (LGL98_01645) 360576..360875 + 300 WP_136033728.1 helix-turn-helix transcriptional regulator Antitoxin
LGL98_RS01650 (LGL98_01650) 360938..362446 - 1509 WP_008806993.1 glycerol-3-phosphate dehydrogenase -
LGL98_RS01655 (LGL98_01655) 362651..362980 + 330 WP_136033726.1 thiosulfate sulfurtransferase GlpE -
LGL98_RS01660 (LGL98_01660) 363031..363861 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LGL98_RS01665 (LGL98_01665) 363911..364669 + 759 WP_136033724.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13504.56 Da        Isoelectric Point: 6.7217

>T219727 WP_136033730.1 NZ_CP084874:360229-360576 [Klebsiella africana]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSKHLTKER

Download         Length: 348 bp

>T219727 NZ_CP116672:3881386-3881637 [Xanthomonas hortorum pv. pelargonii]
ATGGACACCATCACTTACAGCGCCGCGCGTGCCTCTCTGGCCGACACCATGGACCGTGTCGTCAATGACCATGAGCCGGT
GATCATCACGCGCAGCGGTGAGCGCGCCGTAGTCATGTTGTCGCTGGAAGACTACAAGGCCATGGAAGAGACCGCCTACC
TGCTGCGCAGCCCGAAGAGCGCGCAACGGCTGCTGGAATCCATTGCCCAGCTTGAGGCCGGTCGCGGCAAGGAACGGGAA
CTGGCTGAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10880.67 Da        Isoelectric Point: 10.1465

>AT219727 WP_136033728.1 NZ_CP084874:360576-360875 [Klebsiella africana]
MATLKELMAKQNPESQQRIAAKAAEIRQSVALNLLREELHMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT219727 NZ_CP116672:3881634-3881891 [Xanthomonas hortorum pv. pelargonii]
GTGATTCTGCAGTTTGCTGACAATGCCTGGGAGGACTACCTCTACTGGCAACAGACCGACAAGAAGATGCTCAAACGCAT
CAACGAGTTGATCAAGGCCATTCAGCGCGATCCTTTCCAGGGCATCGGCAAACCCGAACCGTTGCGCCATGCGCTGGCGG
GCTACTGGTCACGCCGCATCAACGACGAACACCGGATTGTCTACAAGGCCGAGAACGGTATCCTGCTGATTGCTCAGGCG
CGCTACCACTACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References