Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 359865..360511 Replicon chromosome
Accession NZ_CP084873
Organism Klebsiella pneumoniae strain 03-9138-2

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag LGL99_RS01655 Protein ID WP_004174016.1
Coordinates 359865..360212 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag LGL99_RS01660 Protein ID WP_004174017.1
Coordinates 360212..360511 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL99_RS01645 (355799) 355799..357232 + 1434 WP_226618849.1 glycogen synthase GlgA -
LGL99_RS01650 (357250) 357250..359697 + 2448 WP_029884517.1 glycogen phosphorylase -
LGL99_RS01655 (359865) 359865..360212 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGL99_RS01660 (360212) 360212..360511 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
LGL99_RS01665 (360574) 360574..362082 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LGL99_RS01670 (362287) 362287..362616 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LGL99_RS01675 (362667) 362667..363497 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LGL99_RS01680 (363547) 363547..364305 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T219711 WP_004174016.1 NZ_CP084873:359865-360212 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T219711 NZ_CP116604:2420264-2420605 [Streptococcus sp. HN38]
ATGGTCTATGAAGTACATTTATCTGCTAAAGCCGAACAAGATTTAGAGGAAATCTACCAGTATTATGTCCGTGAATTTTC
AGAATCAAGTGCTCGAAAGGTGCTTGCATCTCTGAGCACAGCTATCTTGACCTTAGAAATATTTCCAGAGGGATATATTG
ACCTTGACGCTCGTCTGGGACAAGCATTATTCCCAGAAGGAAAAACAAGGATGATTCCTGGAAAACAGCACCTCATCTTC
TATTTGATTCGTGGCTCTCGTGTAGATGTCCTTCGCATTAGAGGAGCAAGAACAGACTACCTAAACAACCTAGACAATCT
ATTCAAGCAAACCCTCAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT219711 WP_004174017.1 NZ_CP084873:360212-360511 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT219711 NZ_CP116604:2419987-2420274 [Streptococcus sp. HN38]
ATGGCAGGATTGGTTAGGGATAGACAGTATAATTTTAGAGTAAATGCACAATTACTGGAACAAGCAAAAATAATCTTATC
GGAAAAAGATATGACCCTTTCTGATGCTCTTAATTTATTTGTAGAAAGGGTGGTGGAAGAGCAAGATTTGCCAATAAAAA
CGGTAGAAGAGGCACGTGCAGAGGCTTTTCTTGATGAGTTGATTGCAGAGCTTGATGAAGGCTACCAAGAAGTTTTATCA
GGACACACGACACCTGCTCGTGAGGTATTCGCCAAATATGGTCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References