Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3946233..3946830 Replicon chromosome
Accession NZ_CP084859
Organism Klebsiella pneumoniae strain SB1139

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag LGM11_RS19555 Protein ID WP_004893639.1
Coordinates 3946513..3946830 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag LGM11_RS19550 Protein ID WP_004142561.1
Coordinates 3946233..3946520 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM11_RS19520 (3942440) 3942440..3942688 + 249 WP_002893037.1 DUF1158 domain-containing protein -
LGM11_RS19525 (3942706) 3942706..3943047 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
LGM11_RS19530 (3943078) 3943078..3944193 - 1116 WP_074180844.1 MBL fold metallo-hydrolase -
LGM11_RS19535 (3944373) 3944373..3944954 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
LGM11_RS19540 (3944954) 3944954..3945322 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
LGM11_RS19545 (3945442) 3945442..3946095 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
LGM11_RS19550 (3946233) 3946233..3946520 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
LGM11_RS19555 (3946513) 3946513..3946830 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM11_RS19560 (3947015) 3947015..3948058 - 1044 WP_023279204.1 DUF2157 domain-containing protein -
LGM11_RS19565 (3948728) 3948728..3949594 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
LGM11_RS19570 (3949703) 3949703..3951130 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T219606 WP_004893639.1 NZ_CP084859:c3946830-3946513 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T219606 NZ_CP116557:c2543916-2543764 [Enterococcus faecalis]
GTGGTGCGTATGAGCGCACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCT
AGGGTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAAAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT219606 WP_004142561.1 NZ_CP084859:c3946520-3946233 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT219606 NZ_CP116557:2543645-2543831 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGAGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTTTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References