Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 350474..351120 Replicon chromosome
Accession NZ_CP084859
Organism Klebsiella pneumoniae strain SB1139

Toxin (Protein)


Gene name higB Uniprot ID A0A486LFK7
Locus tag LGM11_RS01610 Protein ID WP_023301313.1
Coordinates 350474..350821 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag LGM11_RS01615 Protein ID WP_002920557.1
Coordinates 350821..351120 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM11_RS01600 (346400) 346400..347833 + 1434 WP_002920564.1 glycogen synthase GlgA -
LGM11_RS01605 (347851) 347851..350298 + 2448 WP_002920561.1 glycogen phosphorylase -
LGM11_RS01610 (350474) 350474..350821 + 348 WP_023301313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM11_RS01615 (350821) 350821..351120 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
LGM11_RS01620 (351183) 351183..352691 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
LGM11_RS01625 (352896) 352896..353225 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
LGM11_RS01630 (353276) 353276..354106 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
LGM11_RS01635 (354156) 354156..354914 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13506.49 Da        Isoelectric Point: 6.2327

>T219594 WP_023301313.1 NZ_CP084859:350474-350821 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITMADREFSQHLTKER

Download         Length: 348 bp

>T219594 NZ_CP116553:2622090-2622233 [Enterococcus faecalis]
ATGAATGTAAGTGCTAAAATCTATGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT219594 WP_002920557.1 NZ_CP084859:350821-351120 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT219594 NZ_CP116553:c2622424-2622166 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAA
TGATAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCAATTTTATTACTT
AAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAA
GCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFK7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References