Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4680981..4681627 Replicon chromosome
Accession NZ_CP084825
Organism Klebsiella pneumoniae strain SB617

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LGM18_RS23015 Protein ID WP_087785704.1
Coordinates 4681277..4681627 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LGM18_RS23010 Protein ID WP_102095462.1
Coordinates 4680981..4681280 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM18_RS22990 (4676710) 4676710..4677579 + 870 WP_023302423.1 HNH endonuclease -
LGM18_RS22995 (4677773) 4677773..4678348 - 576 WP_136085722.1 hypothetical protein -
LGM18_RS23000 (4678559) 4678559..4679242 - 684 Protein_4503 IS1 family transposase -
LGM18_RS23005 (4679271) 4679271..4680542 - 1272 WP_226555562.1 type I restriction endonuclease -
LGM18_RS23010 (4680981) 4680981..4681280 - 300 WP_102095462.1 XRE family transcriptional regulator Antitoxin
LGM18_RS23015 (4681277) 4681277..4681627 - 351 WP_087785704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM18_RS23020 (4682088) 4682088..4683134 - 1047 WP_023285773.1 helicase RepA family protein -
LGM18_RS23025 (4683218) 4683218..4683403 - 186 WP_023285772.1 AlpA family phage regulatory protein -
LGM18_RS23030 (4683428) 4683428..4684696 - 1269 WP_102098527.1 tyrosine-type recombinase/integrase -
LGM18_RS23035 (4684914) 4684914..4685753 - 840 WP_226555565.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4678559..4689840 11281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13823.83 Da        Isoelectric Point: 8.3519

>T219491 WP_087785704.1 NZ_CP084825:c4681627-4681277 [Klebsiella pneumoniae]
MWTVLFSQRFDDWLSEQDDALQEKVLADLGKLQMYRPELPRPYADTLKGSRYKNMKELRIQFSGQPIRAFYAFDPIRRAI
VLYAGDKSNDKRFYEKLMRIAEDEFAAHLKNLEINQ

Download         Length: 351 bp

>T219491 NZ_CP116479:c44250-43900 [Pseudomonas syringae pv. actinidiae]
ATGAATACATTTGCACTGCGCTTTACTGATGTTGCTCAGCAAAGCCTCGAAGATCAGGTTGAACACCTGGCTGTCACTCA
GGGATTCTCATCAGCTGCTCAACGCATAGATATCCTCATCGATGCCATTCAGGACAAGCTCCTGTCCACCCCGTTGGGCT
ACCCGGTCAGTCCTCAATTGAGTGAGCTGGGCGTACTGCACTATCGTGAGTTGAACACTGACGGATACCGAATTTTTTAC
GAGGTGATGCAGTCAGTTGACATCGATGAGATTGTTATATCGCTTGTATTGGGCGGTAAACAAAGCGTTGAACAGGCATT
GATCCGCTACTGCCTTCTTCAGCCTATTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11207.10 Da        Isoelectric Point: 5.1767

>AT219491 WP_102095462.1 NZ_CP084825:c4681280-4680981 [Klebsiella pneumoniae]
MRTLDDVIAARSPESQARIKEMSDEMILEVGLQMMREELQLSQKYVAEMMGISQPAITQLEQRGNDLKLATLKRYIEAMG
GKLSLDVELPTGKRIAFHI

Download         Length: 300 bp

>AT219491 NZ_CP116479:c44514-44266 [Pseudomonas syringae pv. actinidiae]
ATGCGAGTTGAAACAATTAGCTATTTGAAACGCAACGCAGCCGACCTGCCTCTCGATGAGCCGCTGGTCGTCACGCAAAA
CGGTGTCCCGGCCTACGTGGTGGAGTCTTACGCAGATCGTAAGCGCCGCGATGAGTCAATCGCCTTGGTGAAGCTCCTGG
CCATCAGTTCCCGCGAGTACGCCCAAGGCAAGCACTGTTCCACTGACGAACTCAAGGCCCGATTGAGCAGGAGGTTTGAC
CACAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References