Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 321125..321711 Replicon chromosome
Accession NZ_CP084825
Organism Klebsiella pneumoniae strain SB617

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag LGM18_RS01505 Protein ID WP_002920800.1
Coordinates 321343..321711 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag LGM18_RS01500 Protein ID WP_004174006.1
Coordinates 321125..321346 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM18_RS01480 (317282) 317282..318208 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
LGM18_RS01485 (318205) 318205..319482 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
LGM18_RS01490 (319479) 319479..320246 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
LGM18_RS01495 (320248) 320248..320961 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
LGM18_RS01500 (321125) 321125..321346 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LGM18_RS01505 (321343) 321343..321711 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LGM18_RS01510 (321984) 321984..323300 + 1317 WP_117040000.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
LGM18_RS01515 (323407) 323407..324294 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
LGM18_RS01520 (324291) 324291..325136 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
LGM18_RS01525 (325138) 325138..326208 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 318205..326945 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T219476 WP_002920800.1 NZ_CP084825:321343-321711 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T219476 NZ_CP116477:c2638998-2638684 [Pectobacterium sp. A5351]
ATGCAATTCACCGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
GCAATTGAATCGTCGGATAGTGATCCCATTGCTCCCGATTGAAAAGTATCCGGCAGGCCGCCGGCCGGAGCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACCCACGAGCTGGCAAGTATCCCTGTCCAGGCCCTAGGT
GCGGTGTTTTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCGGCACTAGACTTCCTCATCGACGGGTTCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT219476 WP_004174006.1 NZ_CP084825:321125-321346 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT219476 NZ_CP116477:c2639237-2639001 [Pectobacterium sp. A5351]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACAATGACAGTAGAGCGTGCCTTACTGGTAAGAGCGCGTGAGGCGGG
CATTAATCTGAGTGCTACCCTGACAACTGCCCTGGATGCAGAGCTTCGCTCTCATGAAGCGAAAAAATGGCAGGAAGAAA
ACAGGGAGGCTCTCGCAGCACTAAATCGTTTTCATGATGAGCAGGGGTGTTTCAGCGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References