Detailed information of TA system TA021941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 2105365..2105910
• Replicon: chromosome
• Accession: NC_008800
• Organism: Yersinia enterocolitica subsp. enterocolitica 8081

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: A0A8B6KSX9
• Locus tag: YE_RS09675
• Protein ID: WP_005170383.1
• Coordinates: 2105632..2105910 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: A1JMP6
• Locus tag: YE_RS09670
• Protein ID: WP_011816235.1
• Coordinates: 2105365..2105625 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YE_RS09640 (YE1921)	2100789..2101721	-	933	WP_011816229.1	Rpn family recombination-promoting nuclease/putative transposase	-
YE_RS09645 (YE1922)	2101983..2102270	+	288	WP_011816230.1	type II toxin-antitoxin system RelE/ParE family toxin	-
YE_RS09650 (YE1923)	2102270..2102584	+	315	WP_011816231.1	HigA family addiction module antidote protein	-
YE_RS09655 (YE1924)	2102751..2103647	-	897	WP_011816232.1	Rpn family recombination-promoting nuclease/putative transposase	-
YE_RS21595 (YE1925)	2103853..2104029	-	177	WP_165442614.1	hypothetical protein	-
YE_RS09660 (YE1926)	2104468..2104788	-	321	WP_011816233.1	hypothetical protein	-
YE_RS09665	2104778..2104984	-	207	WP_005170388.1	host cell division inhibitor Icd-like protein	-
YE_RS09670 (YE1928)	2105365..2105625	+	261	WP_011816235.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
YE_RS09675 (YE1929)	2105632..2105910	+	279	WP_005170383.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
YE_RS09680 (YE1930)	2105953..2106567	-	615	WP_011816236.1	tail fiber assembly protein	-
YE_RS21675 (YE1931)	2106567..2107515	-	949	Protein_1868	phage tail protein	-
YE_RS09690	2107915..2108211	-	297	WP_042661411.1	NINE protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 11033.77 Da
• Isoelectric Point: 9.8470

>T21941 WP_005170383.1 NC_008800:2105632-2105910 [Yersinia enterocolitica subsp. enterocolitica 8081]
MTKQREIEYSGQFQKDVKKAQKRHKDMNKLKVIMTLLINDKLPLPVVYKDHQLQGNYKGYRDAHIEPDWLIIYKITDDLL
RFERTGSHSDLF

Nucleotide

• Length: 279 bp

>T21941 NC_008800:2105632-2105910 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGACTAAACAAAGGGAAATTGAATATTCAGGTCAGTTCCAGAAAGATGTGAAAAAAGCTCAGAAGCGCCATAAAGATAT
GAATAAACTTAAAGTCATTATGACGCTTCTGATTAACGATAAATTGCCCTTGCCTGTTGTATATAAGGATCATCAATTAC
AAGGTAATTATAAAGGCTACAGGGACGCACATATAGAGCCAGACTGGCTTATCATCTACAAAATTACTGATGATTTGCTT
CGCTTCGAAAGGACAGGAAGCCATTCTGATCTATTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9307.69 Da
• Isoelectric Point: 5.0758

>AT21941 WP_011816235.1 NC_008800:2105365-2105625 [Yersinia enterocolitica subsp. enterocolitica 8081]
MAANAFVRARIDETLKNEAAAVLADMGLTVSDLVRITLTKVAREKALPFDLRIPNEITANTIANSDKGVDVHKAKDADDL
FDKLGI

Nucleotide

• Length: 261 bp

>AT21941 NC_008800:2105365-2105625 [Yersinia enterocolitica subsp. enterocolitica 8081]
ATGGCTGCAAATGCTTTTGTTCGTGCTCGTATAGACGAAACCCTAAAGAATGAAGCCGCTGCTGTACTTGCTGACATGGG
TTTAACCGTATCCGATCTGGTGCGGATAACCTTAACCAAGGTTGCCCGAGAAAAAGCGCTTCCGTTCGATTTGCGTATTC
CTAACGAAATTACAGCTAATACCATTGCCAACAGCGATAAAGGTGTCGATGTCCATAAAGCAAAGGATGCTGATGATCTT
TTTGATAAATTAGGTATCTGA

Structures

Toxin

• AlphaFold DB: A0A8B6KSX9

Antitoxin

• AlphaFold DB: A1JMP6