Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1318634..1319231 Replicon chromosome
Accession NZ_CP084783
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain 09A323

Toxin (Protein)


Gene name higB Uniprot ID A0A3T0QUS6
Locus tag LGM26_RS06210 Protein ID WP_017899012.1
Coordinates 1318634..1318951 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A3T0QUV3
Locus tag LGM26_RS06215 Protein ID WP_017899013.1
Coordinates 1318944..1319231 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM26_RS06195 (1314468) 1314468..1315895 - 1428 WP_017900841.1 MFS transporter -
LGM26_RS06200 (1316004) 1316004..1316873 + 870 WP_017900842.1 helix-turn-helix transcriptional regulator -
LGM26_RS06205 (1317406) 1317406..1318449 + 1044 WP_136070564.1 DUF2157 domain-containing protein -
LGM26_RS06210 (1318634) 1318634..1318951 + 318 WP_017899012.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM26_RS06215 (1318944) 1318944..1319231 + 288 WP_017899013.1 helix-turn-helix transcriptional regulator Antitoxin
LGM26_RS06220 (1319489) 1319489..1320142 - 654 WP_004202485.1 oxygen-insensitive NAD(P)H nitroreductase -
LGM26_RS06225 (1320262) 1320262..1320630 - 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
LGM26_RS06230 (1320630) 1320630..1321211 - 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
LGM26_RS06235 (1321391) 1321391..1322506 + 1116 WP_025999133.1 MBL fold metallo-hydrolase -
LGM26_RS06240 (1322537) 1322537..1322878 + 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
LGM26_RS06245 (1322896) 1322896..1323144 - 249 WP_002893037.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12185.52 Da        Isoelectric Point: 11.2767

>T219393 WP_017899012.1 NZ_CP084783:1318634-1318951 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKTPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T219393 NZ_CP116405:773626-773922 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10840.52 Da        Isoelectric Point: 10.2213

>AT219393 WP_017899013.1 NZ_CP084783:1318944-1319231 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT219393 NZ_CP116405:773924-774319 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0QUS6

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0QUV3

References