Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 64821..65481 Replicon plasmid pKqs_SB610_5
Accession NZ_CP084775
Organism Klebsiella quasipneumoniae subsp. similipneumoniae strain SB610

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LGM29_RS29105 Protein ID WP_226550201.1
Coordinates 65128..65481 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LGM29_RS29100 Protein ID WP_041146308.1
Coordinates 64821..65123 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGM29_RS29085 (LGM29_29085) 60279..63176 - 2898 WP_023307208.1 Tn3-like element Tn5403 family transposase -
LGM29_RS29090 (LGM29_29090) 63271..63876 + 606 WP_000509966.1 recombinase family protein -
LGM29_RS29095 (LGM29_29095) 63912..64580 + 669 Protein_71 beta-ketoacyl synthase N-terminal-like domain-containing protein -
LGM29_RS29100 (LGM29_29100) 64821..65123 - 303 WP_041146308.1 XRE family transcriptional regulator Antitoxin
LGM29_RS29105 (LGM29_29105) 65128..65481 - 354 WP_226550201.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGM29_RS29110 (LGM29_29110) 65800..68487 - 2688 WP_115192343.1 cation-transporting P-type ATPase -
LGM29_RS29115 (LGM29_29115) 68538..68969 - 432 WP_226550204.1 universal stress protein -
LGM29_RS29120 (LGM29_29120) 69244..69941 + 698 WP_095033700.1 IS1-like element IS1B family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94734 94734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13338.33 Da        Isoelectric Point: 7.5707

>T219359 WP_226550201.1 NZ_CP084775:c65481-65128 [Klebsiella quasipneumoniae subsp. similipneumoniae]
VWIIKTTDRFDGWFSTLCATDRACVLALLLVLRERGPGLSRPYADTLKGSCYGNMKELRVQSRGDPIRVFFAFDPCRAGI
LLCAGHKVGNEKRFYEQTIPIADREFTDYLNTLDDKE

Download         Length: 354 bp

>T219359 NZ_CP116348:99821-100237 [Enterobacter ludwigii]
GTGAACAAGACCTATATGCTGGACACCAACATCTGCTCATTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
TGAGCAGGCGGTGCTGCGTAACCAGCGCATCGTTGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCACATCGAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCGCTGCGCATGGCCGGCACGCCGATCGGCCCGAACGACACGGCTATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTAGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11013.75 Da        Isoelectric Point: 5.7251

>AT219359 WP_041146308.1 NZ_CP084775:c65123-64821 [Klebsiella quasipneumoniae subsp. similipneumoniae]
MGRTLEQLLADEKPEVVADAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVASMEKQGRDLKLSTLKRYVEAA
GGKLRLDVELPDGSHFGFAL

Download         Length: 303 bp

>AT219359 NZ_CP116348:99594-99824 [Enterobacter ludwigii]
ATGAGAACCGTATCTATTTTCAAAAATGGCAACAACCGCGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References